Seroatlas · Human Serome Atlas

ACSM4

Acyl-coenzyme A synthetase ACSM4, mitochondrial

Also known as: ACSM4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7M7
Gene: ACSM4
Ensembl: ENSG00000215009
Chromosome: 12
Canonical length: 580 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable decanoate-CoA ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

580 residues, UniProt reviewed canonical sequence.

>P0C7M7|ACSM4
     1  MKIFFRYQTF RFIWLTKPPG RRLHKDHQLW TPLTLADFEA INRCNRPLPK NFNFAADVLD
    61  QWSQKEKTGE RPANPALWWV NGKGDEVKWS FRELGSLSRK AANVLTKPCG LQRGDRLAVI
   121  LPRIPEWWLV NVACIRTGII FMPGTIQLTA KDILYRLRAS KAKCIVASEE VAPAVESIVL
   181  ECPDLKTKLL VSPQSWNGWL SFQELFQFAS EEHSCVETGS QEPMTIYFTS GTTGFPKMAQ
   241  HSQSSLGIGF TLCGRYWLDL KSSDIIWNMS DTGWVKAAIG SVFSSWLCGA CVFVHRMAQF
   301  DTDTFLDTLT TYPITTLCSP PTVYRMLVQK DLKRYKFKSL RHCLTGGEPL NPEVLEQWRV
   361  QTGLELYEGY GQTEVGMICA NQKGQEIKPG SMGKGMLPYD VQIIDENGNV LPPGKEGEIA
   421  LRLKPTRPFC FFSKYVDNPQ KTAATIRGDF YVTGDRGVMD SDGYFWFVGR ADDVIISSGY
   481  RIGPFEVESA LIEHPAVVES AVVSSPDQIR GEVVKAFVVL AAPFKSYNPE KLTLELQDHV
   541  KKSTAPYKYP RKVEFVQELP KTITGKIKRN VLRDQEWRGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACSM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 0.7 nTPM

Expression across tissuesHPA

Tissue

testis: 0.7 nTPM
retina: 0.4 nTPM
spleen: 0.4 nTPM
small intestine: 0.3 nTPM
appendix: 0.2 nTPM
duodenum: 0.2 nTPM

Single-cell type

retinal ganglion cells: 19 nCPM
retinal amacrine cells: 6.2 nCPM
macrophages: 5.5 nCPM
undifferentiated spermatogonia: 5.2 nCPM
neutrophils: 2.4 nCPM
epicardial cells: 2.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 2.3 nTPM
cerebral cortex: 1.4 nTPM
medulla oblongata: 1.2 nTPM
thalamus: 0.8 nTPM
white matter: 0.8 nTPM
amygdala: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.91
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACSM4 as an antibody target. Whether an autoantibody or antibody against ACSM4 could matter depends on whether native ACSM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACSM4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACSM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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