Seroatlas · Human Serome Atlas

ACSM3

Acyl-coenzyme A synthetase ACSM3, mitochondrial

Also known as: ACSM3_HUMAN, SA, SAH

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53FZ2
Gene: ACSM3
Ensembl: ENSG00000005187
Chromosome: 16
Canonical length: 586 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables medium-chain fatty acid-CoA ligase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Located in mitochondrion. Implicated in IgA glomerulonephritis. Biomarker of ulcerative colitis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

586 residues, UniProt reviewed canonical sequence.

>Q53FZ2|ACSM3
     1  MLARVTRKML RHAKCFQRLA IFGSVRALHK DNRTATPQNF SNYESMKQDF KLGIPEYFNF
    61  AKDVLDQWTD KEKAGKKPSN PAFWWINRNG EEMRWSFEEL GSLSRKFANI LSEACSLQRG
   121  DRVILILPRV PEWWLANVAC LRTGTVLIPG TTQLTQKDIL YRLQSSKANC IITNDVLAPA
   181  VDAVASKCEN LHSKLIVSEN SREGWGNLKE LMKHASDSHT CVKTKHNEIM AIFFTSGTSG
   241  YPKMTAHTHS SFGLGLSVNG RFWLDLTPSD VMWNTSDTGW AKSAWSSVFS PWIQGACVFT
   301  HHLPRFEPTS ILQTLSKYPI TVFCSAPTVY RMLVQNDITS YKFKSLKHCV SAGEPITPDV
   361  TEKWRNKTGL DIYEGYGQTE TVLICGNFKG MKIKPGSMGK PSPAFDVKIV DVNGNVLPPG
   421  QEGDIGIQVL PNRPFGLFTH YVDNPSKTAS TLRGNFYITG DRGYMDKDGY FWFVARADDV
   481  ILSSGYRIGP FEVENALNEH PSVAESAVVS SPDPIRGEVV KAFVVLNPDY KSHDQEQLIK
   541  EIQEHVKKTT APYKYPRKVE FIQELPKTIS GKTKRNELRK KEWKTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACSM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 166 nTPM

Expression across tissuesHPA

Tissue

liver: 166 nTPM
kidney: 79 nTPM
ovary: 73 nTPM
breast: 57 nTPM
pancreas: 29 nTPM
stomach: 28 nTPM

Single-cell type

granulosa cells: 1,620 nCPM
ovarian stromal cells: 977 nCPM
sertoli cells: 564 nCPM
proximal tubule cells: 319 nCPM
megakaryocyte-erythroid progenitors: 245 nCPM
mesothelial cells: 223 nCPM

Immune cell

eosinophil: 24 nTPM
naive CD8 T-cell: 8.2 nTPM
naive CD4 T-cell: 6.9 nTPM
T-reg: 5.5 nTPM
memory CD4 T-cell: 4.5 nTPM
MAIT T-cell: 4.2 nTPM

Brain region

white matter: 20 nTPM
medulla oblongata: 16 nTPM
cerebral cortex: 15 nTPM
midbrain: 15 nTPM
pons: 15 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATP binding
fatty acid ligase activity
fatty-acyl-CoA synthase activity
medium-chain fatty acid-CoA ligase activity
metal ion binding
propionate-CoA ligase activity
2-methylbutanoate-CoA ligase activity
propionate CoA-transferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACSM3 as an antibody target. Whether an autoantibody or antibody against ACSM3 could matter depends on whether native ACSM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACSM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACSM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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