Seroatlas · Human Serome Atlas

ACSM1

Acyl-coenzyme A synthetase ACSM1, mitochondrial

Also known as: ACSM1_HUMAN, BUCS1, MACS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q08AH1
Gene: ACSM1
Ensembl: ENSG00000166743
Chromosome: 16
Canonical length: 577 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables benzoate-CoA ligase activity; decanoate-CoA ligase activity; and long-chain fatty acid-CoA ligase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

577 residues, UniProt reviewed canonical sequence.

>Q08AH1|ACSM1
     1  MQWLMRFRTL WGIHKSFHNI HPAPSQLRCR SLSEFGAPRW NDYEVPEEFN FASYVLDYWA
    61  QKEKEGKRGP NPAFWWVNGQ GDEVKWSFRE MGDLTRRVAN VFTQTCGLQQ GDHLALMLPR
   121  VPEWWLVAVG CMRTGIIFIP ATILLKAKDI LYRLQLSKAK GIVTIDALAS EVDSIASQCP
   181  SLKTKLLVSD HSREGWLDFR SLVKSASPEH TCVKSKTLDP MVIFFTSGTT GFPKMAKHSH
   241  GLALQPSFPG SRKLRSLKTS DVSWCLSDSG WIVATIWTLV EPWTAGCTVF IHHLPQFDTK
   301  VIIQTLLKYP INHFWGVSSI YRMILQQDFT SIRFPALEHC YTGGEVVLPK DQEEWKRRTG
   361  LLLYENYGQS ETGLICATYW GMKIKPGFMG KATPPYDVQV IDDKGSILPP NTEGNIGIRI
   421  KPVRPVSLFM CYEGDPEKTA KVECGDFYNT GDRGKMDEEG YICFLGRSDD IINASGYRIG
   481  PAEVESALVE HPAVAESAVV GSPDPIRGEV VKAFIVLTPQ FLSHDKDQLT KELQQHVKSV
   541  TAPYKYPRKV EFVSELPKTI TGKIERKELR KKETGQM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACSM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 202 nTPM

Expression across tissuesHPA

Tissue

breast: 202 nTPM
liver: 9.4 nTPM
testis: 4.2 nTPM
prostate: 3.5 nTPM
bone marrow: 3.4 nTPM
ovary: 3.1 nTPM

Single-cell type

epicardial cells: 432 nCPM
fibroblasts: 172 nCPM
granulosa cells: 48 nCPM
late spermatids: 46 nCPM
ovarian stromal cells: 41 nCPM
sertoli cells: 39 nCPM

Immune cell

memory B-cell: 1.7 nTPM
eosinophil: 1.3 nTPM
naive B-cell: 0.8 nTPM
NK-cell: 0.5 nTPM
classical monocyte: 0.3 nTPM
memory CD4 T-cell: 0.2 nTPM

Brain region

cerebral cortex: 0.7 nTPM
pons: 0.7 nTPM
cerebellum: 0.6 nTPM
hypothalamus: 0.6 nTPM
medulla oblongata: 0.6 nTPM
thalamus: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

acyl-CoA metabolic process
cholesterol homeostasis
energy derivation by oxidation of organic compounds
fatty acid biosynthetic process
fatty acid oxidation
xenobiotic metabolic process
benzoate metabolic process
butyrate metabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACSM1 as an antibody target. Whether an autoantibody or antibody against ACSM1 could matter depends on whether native ACSM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACSM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACSM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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