Seroatlas · Human Serome Atlas

TUBGCP5

Gamma-tubulin complex component 5

Also known as: GCP5, GCP5_HUMAN, KIAA1899

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96RT8
Gene: TUBGCP5
Ensembl: ENSG00000275835
Chromosome: 15
Canonical length: 1024 aa
Protein class: Predicted intracellular proteins
Subcellular location: Primary cilium,Primary cilium transition zone,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome; ciliary basal body; and cytosol. Part of gamma-tubulin ring complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1024 residues, UniProt reviewed canonical sequence.

>Q96RT8|TUBGCP5
     1  MARHGPPWSR LDAQQERDVR ELVRGVAGLQ DEADPNFQLA LNFAWSNFRF HRFLDVNSHK
    61  IEKTIEGIYE KFVIHSDLSK AASWKRLTEE FLNAPLPSIK EIKTDAHYSI LSLLLCLSDS
   121  PSNSSYVETP RNKEVEKKDD FDWGKYLMED EEMDIGPYMD TPNWSEESEE ENDQQPLSRE
   181  DSGIQVDRTP LEEQDQNRKL DPCISWKDEP DDRSWLEHHV VHQYWTARPS QFPHSLHLHS
   241  NLAAVWDQHL YSSDPLYVPD DRVLVTETQV IRETLWLLSG VKKLFIFQLI DGKVTVRNNI
   301  IVTHLTHSCL RSVLEQIAAY GQVVFRLQEF IDEVMGHSSE SMLPGSGSVP KKSTEAPFRT
   361  YQAFMWALYK YFISFKEELA EIEKCIINND TTITLAIVVD KLAPRLSQLK VLHKVFSTGV
   421  AEVPPDTRNV VRASHLLNTL YKAILEYDNV GEASEQTVSL LFSLWVETVR PYLQTVDEWI
   481  VHGHLWDGAR EFIIQRNKNV PVNHRDFWYA TYTLYSVSEK TENEEKMSDN ASASSGSDQG
   541  PSSRQHTMVS FLKPVLKQII MAGKSMQLLK NLQCAESTTC QAGARDAERK SLYTLFLESV
   601  QSRLRHGEDS TPQVLTEQQA TKENLMKMQS IAESHLELDD VHDPLLAINF ARMYLEQSDF
   661  HEKFAGGDVC VDRSSESVTC QTFELTLRSC LYPHIDKQYL DCCGNLMQTL KKDYRLVEYL
   721  QAMRNFFLME GGDTMYDFYT SIFDKIREKE TWQNVSFLNV QLQEAVGQRY PEDSSRLSIS
   781  FENVDTAKKK LPVHILDGLT LSYKVPWPVD IVISLECQKI YNQVFLLLLQ IKWAKYSLDV
   841  LLFGELVSTA EKPRLKEGLI HEQDTVAQFG PQKEPVRQQI HRMFLLRVKL MHFVNSLHNY
   901  IMTRILHSTG LEFQHQVEEA KDLDQLIKIH YRYLSTIHDR CLLREKVSFV KEAIMKVLNL
   961  ALMFADGWQA GLGTWRMESI EKMESDFKNC HMFLVTILNK AVCRGSFPHL ESLALSLMAG
  1021  MEQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBGCP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
thyroid gland: 11 nTPM
skeletal muscle: 10 nTPM
pancreas: 10 nTPM
tongue: 9.5 nTPM
cerebral cortex: 9.4 nTPM

Single-cell type

microglia: 42 nCPM
oligodendrocytes: 38 nCPM
other brain neurons: 38 nCPM
brain inhibitory neurons: 36 nCPM
distal convoluted tubule cells: 34 nCPM
proximal tubule cells: 34 nCPM

Immune cell

naive CD8 T-cell: 4.7 nTPM
memory CD8 T-cell: 4.4 nTPM
naive B-cell: 4.2 nTPM
memory CD4 T-cell: 4.1 nTPM
NK-cell: 3.9 nTPM
T-reg: 3.7 nTPM

Brain region

cerebral cortex: 25 nTPM
white matter: 25 nTPM
pons: 22 nTPM
medulla oblongata: 22 nTPM
hypothalamus: 21 nTPM
thalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0
gnomAD missense Z: 1.37
DepMap mean gene effect: -1.1
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Gamma-tubulin complex component protein
Gamma tubulin complex component, C-terminal
Gamma tubulin complex component protein, N-terminal
Gamma tubulin complex component, C-terminal domain superfamily
Gamma tubulin complex component C-terminal
Gamma tubulin complex component N-terminal
Gamma-tubulin complex component 5, N-terminal extension

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUBGCP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBGCP5 as an antibody target. Whether an autoantibody or antibody against TUBGCP5 could matter depends on whether native TUBGCP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBGCP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBGCP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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