MZT1
Mitotic-spindle organizing protein 1
Also known as: C13orf37, FLJ21869, LOC440145, MGC150539, MOZART1, MZT1_HUMAN, RP11-11C5.2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q08AG7
- Gene
- MZT1
- Ensembl
- ENSG00000204899
- Chromosome
- 13
- Canonical length
- 82 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Involved in gamma-tubulin complex localization. Located in centrosome and spindle. Part of gamma-tubulin ring complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
82 residues, UniProt reviewed canonical sequence.
>Q08AG7|MZT1
1 MASSSGAGAA AAAAAANLNA VRETMDVLLE ISRILNTGLD METLSICVRL CEQGINPEAL
61 SSVIKELRKA TEALKAAENM TSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MZT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 37 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 37 nTPM
- bone marrow: 25 nTPM
- cerebellum: 24 nTPM
- amygdala: 18 nTPM
- skeletal muscle: 18 nTPM
- cerebral cortex: 18 nTPM
Single-cell type
- extravillous trophoblasts: 121 nCPM
- gastric progenitor cells: 103 nCPM
- megakaryocytes: 99 nCPM
- migrating cytotrophoblasts: 80 nCPM
- erythrocyte progenitors: 76 nCPM
- parietal cells: 73 nCPM
Immune cell
- basophil: 16 nTPM
- T-reg: 9.9 nTPM
- eosinophil: 8.5 nTPM
- naive CD4 T-cell: 8.3 nTPM
- memory B-cell: 7.7 nTPM
- non-classical monocyte: 7.6 nTPM
Brain region
- basal ganglia: 19 nTPM
- hypothalamus: 14 nTPM
- cerebral cortex: 13 nTPM
- cerebellum: 13 nTPM
- hippocampal formation: 12 nTPM
- amygdala: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.71
- gnomAD pLI
- 0.05
- gnomAD missense Z
- 0.2
- DepMap mean gene effect
- -1.38
- DepMap dependency class
- pan
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- gamma-tubulin complex localization
- mitotic spindle assembly
- microtubule nucleation by interphase microtubule organizing center
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Mitotic-spindle organizing protein 1
- Mitotic-spindle organizing gamma-tubulin ring associated
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MZT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MZT1 as an antibody target. Whether an autoantibody or antibody against MZT1 could matter depends on whether native MZT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MZT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MZT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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