Seroatlas · Human Serome Atlas

PRICKLE3

Prickle planar cell polarity protein 3

Also known as: LMO6, PRIC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43900
Gene: PRICKLE3
Ensembl: ENSG00000012211
Chromosome: X
Canonical length: 615 aa
Protein class: Disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

LIM domain only 6 is a three LIM domain-containing protein. The LIM domain is a cysteine-rich sequence motif that binds zinc atoms to form a specific protein-binding interface for protein-protein interactions. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

615 residues, UniProt reviewed canonical sequence.

>O43900|PRICKLE3
     1  MFARGSRRRR SGRAPPEAED PDRGQPCNSC REQCPGFLLH GWRKICQHCK CPREEHAVHA
    61  VPVDLERIMC RLISDFQRHS ISDDDSGCAS EEYAWVPPGL KPEQVYQFFS CLPEDKVPYV
   121  NSPGEKYRIK QLLHQLPPHD SEAQYCTALE EEEKKELRAF SQQRKRENLG RGIVRIFPVT
   181  ITGAICEECG KQIGGGDIAV FASRAGLGAC WHPQCFVCTT CQELLVDLIY FYHVGKVYCG
   241  RHHAECLRPR CQACDEIIFS PECTEAEGRH WHMDHFCCFE CEASLGGQRY VMRQSRPHCC
   301  ACYEARHAEY CDGCGEHIGL DQGQMAYEGQ HWHASDRCFC CSRCGRALLG RPFLPRRGLI
   361  FCSRACSLGS EPTAPGPSRR SWSAGPVTAP LAASTASFSA VKGASETTTK GTSTELAPAT
   421  GPEEPSRFLR GAPHRHSMPE LGLRSVPEPP PESPGQPNLR PDDSAFGRQS TPRVSFRDPL
   481  VSEGGPRRTL SAPPAQRRRP RSPPPRAPSR RRHHHHNHHH HHNRHPSRRR HYQCDAGSGS
   541  DSESCSSSPS SSSSESSEDD GFFLGERIPL PPHLCRPMPA QDTAMETFNS PSLSLPRDSR
   601  AGMPRQARDK NCIVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRICKLE3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 15 nTPM
esophagus: 14 nTPM
skin: 11 nTPM
tongue: 9.7 nTPM
vagina: 9.7 nTPM
cervix: 7.1 nTPM

Single-cell type

late spermatids: 186 nCPM
early spermatids: 99 nCPM
esophageal suprabasal cells: 33 nCPM
late primary spermatocytes: 28 nCPM
esophageal basal cells: 26 nCPM
suprabasal keratinocytes: 25 nCPM

Immune cell

non-classical monocyte: 12 nTPM
eosinophil: 9.2 nTPM
intermediate monocyte: 9.1 nTPM
classical monocyte: 8.3 nTPM
myeloid DC: 7.5 nTPM
memory B-cell: 6.9 nTPM

Brain region

choroid plexus: 7.4 nTPM
white matter: 5.2 nTPM
spinal cord: 5 nTPM
cerebral cortex: 4.8 nTPM
thalamus: 4.7 nTPM
medulla oblongata: 4.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRICKLE3.

Disease | AllUniProt

Conditions PRICKLE3 is implicated in, by any mechanism.

Leber hereditary optic neuropathy, modifier (LOAM) MIM:308905

Disease | ImmuneIEDB

Conditions an epitope on PRICKLE3 was assayed in.

melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.63
gnomAD missense Z: 1.19
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell projection organization

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRICKLE3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRICKLE3 as an antibody target. Whether an autoantibody or antibody against PRICKLE3 could matter depends on whether native PRICKLE3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRICKLE3 is annotated at the cell surface, where native PRICKLE3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRICKLE3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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