Seroatlas · Human Serome Atlas

TUBGCP2

Gamma-tubulin complex component 2

Also known as: GCP2, GCP2_HUMAN, SPBC97, Spc97p

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BSJ2
Gene
TUBGCP2
Ensembl
ENSG00000130640
Chromosome
10
Canonical length
902 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome,Basal body

OverviewNCBI Gene

Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Involved in brain development and neuron migration. Located in centrosome; ciliary basal body; and nucleoplasm. Implicated in pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

902 residues, UniProt reviewed canonical sequence.

>Q9BSJ2|TUBGCP2
     1  MSEFRIHHDV NELLSLLRVH GGDGAEVYID LLQKNRTPYV TTTVSAHSAK VKIAEFSRTP
    61  EDFLKKYDEL KSKNTRNLDP LVYLLSKLTE DKETLQYLQQ NAKERAELAA AAVGSSTTSI
   121  NVPAAASKIS MQELEELRKQ LGSVATGSTL QQSLELKRKM LRDKQNKKNS GQHLPIFPAW
   181  VYERPALIGD FLIGAGISTD TALPIGTLPL ASQESAVVED LLYVLVGVDG RYVSAQPLAG
   241  RQSRTFLVDP NLDLSIRELV HRILPVAASY SAVTRFIEEK SSFEYGQVNH ALAAAMRTLV
   301  KEHLILVSQL EQLHRQGLLS LQKLWFYIQP AMRTMDILAS LATSVDKGEC LGGSTLSLLH
   361  DRSFSYTGDS QAQELCLYLT KAASAPYFEV LEKWIYRGII HDPYSEFMVE EHELRKERIQ
   421  EDYNDKYWDQ RYTIVQQQIP SFLQKMADKI LSTGKYLNVV RECGHDVTCP VAKEIIYTLK
   481  ERAYVEQIEK AFNYASKVLL DFLMEEKELV AHLRSIKRYF LMDQGDFFVH FMDLAEEELR
   541  KPVEDITPPR LEALLELALR MSTANTDPFK DDLKIDLMPH DLITQLLRVL AIETKQEKAM
   601  AHADPTELAL SGLEAFSFDY IVKWPLSLII NRKALTRYQM LFRHMFYCKH VERQLCSVWI
   661  SNKTAKQHSL HSAQWFAGAF TLRQRMLNFV QNIQYYMMFE VMEPTWHILE KNLKSASNID
   721  DVLGHHTGFL DTCLKDCMLT NPELLKVFSK LMSVCVMFTN CMQKFTQSMK LDGELGGQTL
   781  EHSTVLGLPA GAEERARKEL ARKHLAEHAD TVQLVSGFEA TINKFDKNFS AHLLDLLARL
   841  SIYSTSDCEH GMASVISRLD FNGFYTERLE RLSAERSQKA TPQVPVLRGP PAPAPRVAVT
   901  AQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBGCP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 31 nTPM
  • kidney: 27 nTPM
  • adrenal gland: 24 nTPM
  • cerebral cortex: 24 nTPM
  • cerebellum: 24 nTPM
  • ovary: 22 nTPM

Single-cell type

  • cardiomyocytes: 260 nCPM
  • fallopian tube ciliated cells: 170 nCPM
  • respiratory ciliated cells: 137 nCPM
  • mast cells: 98 nCPM
  • monocytes: 98 nCPM
  • proximal tubule cells: 96 nCPM

Immune cell

  • myeloid DC: 25 nTPM
  • NK-cell: 25 nTPM
  • non-classical monocyte: 22 nTPM
  • intermediate monocyte: 21 nTPM
  • classical monocyte: 19 nTPM
  • total PBMC: 17 nTPM

Brain region

  • hypothalamus: 18 nTPM
  • pons: 17 nTPM
  • medulla oblongata: 16 nTPM
  • white matter: 15 nTPM
  • spinal cord: 15 nTPM
  • choroid plexus: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TUBGCP2.

Disease | AllUniProt

Conditions TUBGCP2 is implicated in, by any mechanism.

  • Cortical dysplasia, complex, with other brain malformations 15 (CDCBM15) MIM:618737

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 244 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0
gnomAD missense Z
1.24
DepMap mean gene effect
-1.25
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUBGCP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBGCP2 as an antibody target. Whether an autoantibody or antibody against TUBGCP2 could matter depends on whether native TUBGCP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBGCP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBGCP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TUBGCP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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