MZT2B
Mitotic-spindle organizing protein 2B
Also known as: FAM128B, FLJ14346, MOZART2B, MZT2B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6NZ67
- Gene
- MZT2B
- Ensembl
- ENSG00000152082
- Chromosome
- 2
- Canonical length
- 158 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Centrosome,Cytosol
OverviewNCBI Gene
Located in cytosol; microtubule cytoskeleton; and nucleoplasm. Part of gamma-tubulin ring complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
158 residues, UniProt reviewed canonical sequence.
>Q6NZ67|MZT2B
1 MAAQGVGPGP GSAAPPGLEA ARQKLALRRK KVLSTEEMEL YELAQAAGGA IDPDVFKILV
61 DLLKLNVAPL AVFQMLKSMC AGQRLASEPQ DPAAVSLPTS SVPETRGRNK GSAALGGALA
121 LAERSSREGS SQRMPRQPSA TRLPKGGGPG KSPTRGSTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MZT2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.62
- Highest tissue expression
- 569 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 569 nTPM
- amygdala: 550 nTPM
- cerebral cortex: 471 nTPM
- pancreas: 408 nTPM
- hippocampal formation: 363 nTPM
- basal ganglia: 348 nTPM
Single-cell type
- late spermatids: 2,051 nCPM
- epididymal efferent duct absorptive cells: 990 nCPM
- decidual stromal cells: 865 nCPM
- epididymal principal cells: 702 nCPM
- esophageal basal cells: 671 nCPM
- esophageal suprabasal cells: 619 nCPM
Immune cell
- eosinophil: 83 nTPM
- plasmacytoid DC: 48 nTPM
- naive B-cell: 39 nTPM
- memory B-cell: 38 nTPM
- naive CD4 T-cell: 29 nTPM
- NK-cell: 28 nTPM
Brain region
- cerebral cortex: 242 nTPM
- amygdala: 241 nTPM
- thalamus: 239 nTPM
- medulla oblongata: 219 nTPM
- white matter: 215 nTPM
- basal ganglia: 215 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.57
- gnomAD pLI
- 0.06
- gnomAD missense Z
- -0.35
- DepMap mean gene effect
- -0.23
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MZT2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MZT2B as an antibody target. Whether an autoantibody or antibody against MZT2B could matter depends on whether native MZT2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MZT2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MZT2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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