Seroatlas · Human Serome Atlas

TUBG2

Tubulin gamma-2 chain

Also known as: TBG2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRH3
Gene: TUBG2
Ensembl: ENSG00000037042
Chromosome: 17
Canonical length: 451 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centriolar satellite,Principal piece

OverviewNCBI Gene

Predicted to enable GTP binding activity and microtubule nucleator activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic sister chromatid segregation. Located in microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

451 residues, UniProt reviewed canonical sequence.

>Q9NRH3|TUBG2
     1  MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV FFYQADDEHY
    61  IPRAVLLDLE PRVIHSILNS PYAKLYNPEN IYLSEHGGGA GNNWASGFSQ GEKIHEDIFD
   121  IIDREADGSD SLEGFVLCHS IAGGTGSGLG SYLLERLNDR YPKKLVQTYS VFPYQDEMSD
   181  VVVQPYNSLL TLKRLTQNAD CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST
   241  TTLRYPGYMN NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP
   301  KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP WGPASIQVAL
   361  SRKSPYLPSA HRVSGLMMAN HTSISSLFES SCQQFDKLRK RDAFLEQFRK EDMFKDNFDE
   421  MDRSREVVQE LIDEYHAATQ PDYISWGTQE Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 120 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 120 nTPM
hippocampal formation: 100 nTPM
amygdala: 94 nTPM
basal ganglia: 82 nTPM
pancreas: 73 nTPM
midbrain: 72 nTPM

Single-cell type

erythrocyte progenitors: 56 nCPM
pancreatic acinar cells: 49 nCPM
peritubular myoid cells: 48 nCPM
sertoli cells: 41 nCPM
adrenal cortex cells: 40 nCPM
brain excitatory neurons: 39 nCPM

Immune cell

plasmacytoid DC: 4.5 nTPM
naive CD4 T-cell: 3.5 nTPM
memory CD4 T-cell: 3.3 nTPM
gdT-cell: 3 nTPM
naive CD8 T-cell: 2.3 nTPM
total PBMC: 1.8 nTPM

Brain region

cerebral cortex: 124 nTPM
white matter: 102 nTPM
thalamus: 95 nTPM
pons: 85 nTPM
amygdala: 80 nTPM
medulla oblongata: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: 2.44
DepMap mean gene effect: -0.35
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUBG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TUBG1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBG2 as an antibody target. Whether an autoantibody or antibody against TUBG2 could matter depends on whether native TUBG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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