Seroatlas · Human Serome Atlas

CSTF1

Cleavage stimulation factor subunit 1

Also known as: CSTF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q05048
Gene: CSTF1
Ensembl: ENSG00000101138
Chromosome: 20
Canonical length: 431 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>Q05048|CSTF1
     1  MYRTKVGLKD RQQLYKLIIS QLLYDGYISI ANGLINEIKP QSVCAPSEQL LHLIKLGMEN
    61  DDTAVQYAIG RSDTVAPGTG IDLEFDADVQ TMSPEASEYE TCYVTSHKGP CRVATYSRDG
   121  QLIATGSADA SIKILDTERM LAKSAMPIEV MMNETAQQNM ENHPVIRTLY DHVDEVTCLA
   181  FHPTEQILAS GSRDYTLKLF DYSKPSAKRA FKYIQEAEML RSISFHPSGD FILVGTQHPT
   241  LRLYDINTFQ CFVSCNPQDQ HTDAICSVNY NSSANMYVTG SKDGCIKLWD GVSNRCITTF
   301  EKAHDGAEVC SAIFSKNSKY ILSSGKDSVA KLWEISTGRT LVRYTGAGLS GRQVHRTQAV
   361  FNHTEDYVLL PDERTISLCC WDSRTAERRN LLSLGHNNIV RCIVHSPTNP GFMTCSDDFR
   421  ARFWYRRSTT D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSTF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

testis: 16 nTPM
retina: 14 nTPM
tongue: 14 nTPM
tonsil: 14 nTPM
thymus: 13 nTPM
lymph node: 12 nTPM

Single-cell type

late primary spermatocytes: 109 nCPM
oocytes: 101 nCPM
neutrophils: 45 nCPM
differentiating spermatogonia: 37 nCPM
migrating cytotrophoblasts: 35 nCPM
cytotrophoblasts: 35 nCPM

Immune cell

T-reg: 33 nTPM
NK-cell: 31 nTPM
naive CD4 T-cell: 28 nTPM
MAIT T-cell: 26 nTPM
memory CD4 T-cell: 26 nTPM
naive CD8 T-cell: 25 nTPM

Brain region

cerebellum: 17 nTPM
white matter: 17 nTPM
hypothalamus: 16 nTPM
choroid plexus: 15 nTPM
pons: 15 nTPM
basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.95
gnomAD missense Z: 3.41
DepMap mean gene effect: -0.74
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mRNA 3'-end processing

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40 repeat, conserved site
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
Cleavage stimulation factor subunit 1, dimerisation domain
CSTF1, dimerization domain superfamily
Cleavage stimulation factor subunit 1-like
Cleavage stimulation factor subunit 1, dimerisation domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSTF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSTF1 as an antibody target. Whether an autoantibody or antibody against CSTF1 could matter depends on whether native CSTF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSTF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSTF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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