Seroatlas · Human Serome Atlas

RHOXF2

Rhox homeobox family member 2

Also known as: CT107, PEPP-2, PEPP2, RHXF2_HUMAN, THG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQY4
Gene: RHOXF2
Ensembl: ENSG00000131721
Chromosome: X
Canonical length: 288 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene, which encodes a transcriptional repressor, is one of two paralogous X-linked homeobox-containing genes and is highly expressed in a variety of cancers. In addition, the encoded protein associates with the cell membrane and with microtubules, and is concentrated at the leading edge of migratory cells. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q9BQY4|RHOXF2
     1  MEPPDQCSQY MTSLLSPAVD DEKELQDMNA MVLSLTEEVK EEEEDAQPEP EQGTAAGEKL
    61  KSAGAQGGEE KDGGGEEKDG GGAGVPGHLW EGDLEGTSGS DGNVEDSDQS EKEPGQQYSR
   121  PQGAVGGLEP GNAQQPNVHA FTPLQLQELE RIFQREQFPS EFLRRRLARS MNVTELAVQI
   181  WFENRRAKWR RHQRALMARN MLPFMAVGQP VMVTAAEAIT APLFISGMRD DYFWDHSHSS
   241  SLCFPMPPFP PPSLPLPLML LPPMPPAGQA EFGPFPFVIV PSFTFPNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHOXF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

testis: 3.9 nTPM
skeletal muscle: 0.2 nTPM
cerebellum: 0.1 nTPM
retina: 0.1 nTPM
skin: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

cardiomyocytes: 5.8 nCPM
epicardial cells: 2.3 nCPM
undifferentiated spermatogonia: 1.9 nCPM
differentiating spermatogonia: 1.4 nCPM
early primary spermatocytes: 0.7 nCPM
hematopoietic stem cells: 0.5 nCPM

Immune cell

plasmacytoid DC: 0.2 nTPM
basophil: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 6.5 nTPM
medulla oblongata: 4.3 nTPM
hypothalamus: 4.1 nTPM
midbrain: 3.9 nTPM
cerebral cortex: 3.3 nTPM
choroid plexus: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: 0.12
DepMap mean gene effect: -0.1
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHOXF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHOXF2 as an antibody target. Whether an autoantibody or antibody against RHOXF2 could matter depends on whether native RHOXF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHOXF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RHOXF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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