Seroatlas · Human Serome Atlas

TBC1D15

TBC1 domain family member 15

Also known as: DKFZp761D0223, FLJ12085, TBC15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TC07
Gene: TBC1D15
Ensembl: ENSG00000121749
Chromosome: 12
Canonical length: 691 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

691 residues, UniProt reviewed canonical sequence.

>Q8TC07|TBC1D15
     1  MAAAGVVSGK IIYEQEGVYI HSSCGKTNDQ DGLISGILRV LEKDAEVIVD WRPLDDALDS
    61  SSILYARKDS SSVVEWTQAP KERGHRGSEH LNSYEAEWDM VNTVSFKRKP HTNGDAPSHR
   121  NGKSKWSFLF SLTDLKSIKQ NKEGMGWSYL VFCLKDDVVL PALHFHQGDS KLLIESLEKY
   181  VVLCESPQDK RTLLVNCQNK SLSQSFENLL DEPAYGLIQA GLLDRRKLLW AIHHWKKIKK
   241  DPYTATMIGF SKVTNYIFDS LRGSDPSTHQ RPPSEMADFL SDAIPGLKIN QQEEPGFEVI
   301  TRIDLGERPV VQRREPVSLE EWTKNIDSEG RILNVDNMKQ MIFRGGLSHA LRKQAWKFLL
   361  GYFPWDSTKE ERTQLQKQKT DEYFRMKLQW KSISQEQEKR NSRLRDYRSL IEKDVNRTDR
   421  TNKFYEGQDN PGLILLHDIL MTYCMYDFDL GYVQGMSDLL SPLLYVMENE VDAFWCFASY
   481  MDQMHQNFEE QMQGMKTQLI QLSTLLRLLD SGFCSYLESQ DSGYLYFCFR WLLIRFKREF
   541  SFLDILRLWE VMWTELPCTN FHLLLCCAIL ESEKQQIMEK HYGFNEILKH INELSMKIDV
   601  EDILCKAEAI SLQMVKCKEL PQAVCEILGL QGSEVTTPDS DVGEDENVVM TPCPTSAFQS
   661  NALPTLSASG ARNDSPTQIP VSSDVCRLTP A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 40 nTPM
liver: 29 nTPM
skeletal muscle: 27 nTPM
thyroid gland: 26 nTPM
adrenal gland: 24 nTPM
breast: 24 nTPM

Single-cell type

neutrophils: 486 nCPM
endometrial glandular cells: 261 nCPM
platelets: 250 nCPM
thymic myoid cells: 242 nCPM
late primary spermatocytes: 230 nCPM
pancreatic acinar cells: 213 nCPM

Immune cell

neutrophil: 12 nTPM
T-reg: 11 nTPM
naive CD4 T-cell: 9.5 nTPM
naive CD8 T-cell: 8.7 nTPM
non-classical monocyte: 8.1 nTPM
eosinophil: 7.8 nTPM

Brain region

white matter: 39 nTPM
medulla oblongata: 30 nTPM
pons: 29 nTPM
basal ganglia: 28 nTPM
midbrain: 28 nTPM
cerebellum: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.06
gnomAD missense Z: 0.92
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of GTPase activity

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBC1D15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D15 as an antibody target. Whether an autoantibody or antibody against TBC1D15 could matter depends on whether native TBC1D15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...