CALCOCO1/2, zinc finger UBZ1-type
IPR041641
Definition
The ubiquitin-binding zinc finger (UBZ) is a type of zinc-coordinating β-β-α fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families [[cite:PMID:19213613], [cite:PMID:27062441]]. Type 1 UBZs are CCHH-type zinc fingers found in tandem UBZ domains of TAX1-binding protein 1 (TAX1BP1) [[cite:PMID:24239949], [cite:PMID:26506893], [cite:PMID:27370208]], type 2 UBZs are CCHC-type zinc fingers found in FAAP20 which is a subunit of the Fanconi anemia (FA) core complex [[cite:PMID:25414354], [cite:PMID:25799058]], type 3 UBZs are CCHH-type zinc fingers found only in the Y-family translesion polymerase eta [[cite:PMID:17304240], [cite:PMID:17550419], [cite:PMID:20837403]], and type 4 UBZs are CCHC-type zinc fingers found in Y-family translesion polymerase kappa, Werner helicase-interacting protein 1 (WRNIP1), and Rad18 [[cite:PMID:20385554], [cite:PMID:25162118], [cite:PMID:24794496]]. This entry represents the UBZ1 type zinc finger domain found in calcium-binding and coiled-coil domain 1/2 (CALCOCO1/2), tax-binding protein 1 and protein spindle-F. This domain is a typical C2H2-type zinc finger which specifically recognizes mono-ubiquitin or poly-ubiquitin chain. The overall ubiquitin-binding mode utilizes the C-terminal α-helix to interact with the solvent-exposed surface of the central β-sheet of ubiquitin, similar to that observed in the RABGEF1/Rabex-5 or POLN/Pol-eta zinc finger PMID:26506893. CALCOCO2 (also known as NDP25) is an ubiquitin-binding autophagy receptor involved in the selective autophagic degradation of invading pathogens PMID:26506893. Tax binding protein 1 is a ubiquitin binding protein PMID:28314591 and protein spindle-F plays a role in oocyte axis determination and microtubule organization during oogenesis in Drosophila [[cite:PMID:18796167], [cite:PMID:16540510]].
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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