Seroatlas · Human Serome Atlas

NFAM1

NFAT activation molecule 1

Also known as: CNAIP, NFAM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NET5
Gene: NFAM1
Ensembl: ENSG00000235568
Chromosome: 22
Canonical length: 270 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>Q8NET5|NFAM1
     1  MENQPVRWRA LPGLPRPPGL PAAPWLLLGV LLLPGTLRLA GGQSVTHTGL PIMASLANTA
    61  ISFSCRITYP YTPQFKVFTV SYFHEDLQGQ RSPKKPTNCH PGLGTENQSH TLDCQVTLVL
   121  PGASATGTYY CSVHWPHSTV RGSGTFILVR DAGYREPPQS PQKLLLFGFT GLLSVLSVVG
   181  TALLLWNKKR MRGPGKDPTR KCPDPRSASS PKQHPSESVY TALQRRETEV YACIENEDGS
   241  SPTAKQSPLS QERPHRFEDD GELNLVYENL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NFAM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 29 nTPM
spleen: 19 nTPM
appendix: 12 nTPM
lung: 7.1 nTPM
adipose tissue: 5.9 nTPM
lymph node: 5.1 nTPM

Single-cell type

neutrophils: 560 nCPM
neutrophil progenitors: 128 nCPM
monocytes: 123 nCPM
kupffer cells: 107 nCPM
monocyte progenitors: 55 nCPM
cdc: 50 nCPM

Immune cell

neutrophil: 91 nTPM
classical monocyte: 48 nTPM
intermediate monocyte: 33 nTPM
non-classical monocyte: 31 nTPM
total PBMC: 25 nTPM
myeloid DC: 17 nTPM

Brain region

medulla oblongata: 6.2 nTPM
white matter: 6 nTPM
pons: 5.9 nTPM
thalamus: 5.9 nTPM
hypothalamus: 4.7 nTPM
cerebral cortex: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transmembrane signaling receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Phosphorylated immunoreceptor signalling ITAM
NFAT activation molecule 1
NFAM1, Ig-like domain
NFAM1 immunoglobin domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NFAM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NFAM1 as an antibody target. Whether an autoantibody or antibody against NFAM1 could matter depends on whether native NFAM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NFAM1 is annotated at the cell surface, where native NFAM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NFAM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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