Seroatlas · Human Serome Atlas

MSN

Moesin

Also known as: MOES_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P26038
Gene
MSN
Ensembl
ENSG00000147065
Chromosome
X
Canonical length
577 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

577 residues, UniProt reviewed canonical sequence.

>P26038|MSN
     1  MPKTISVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWFFGLQYQ DTKGFSTWLK
    61  LNKKVTAQDV RKESPLLFKF RAKFYPEDVS EELIQDITQR LFFLQVKEGI LNDDIYCPPE
   121  TAVLLASYAV QSKYGDFNKE VHKSGYLAGD KLLPQRVLEQ HKLNKDQWEE RIQVWHEEHR
   181  GMLREDAVLE YLKIAQDLEM YGVNYFSIKN KKGSELWLGV DALGLNIYEQ NDRLTPKIGF
   241  PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI
   301  EVQQMKAQAR EEKHQKQMER AMLENEKKKR EMAEKEKEKI EREKEELMER LKQIEEQTKK
   361  AQQELEEQTR RALELEQERK RAQSEAEKLA KERQEAEEAK EALLQASRDQ KKTQEQLALE
   421  MAELTARISQ LEMARQKKES EAVEWQQKAQ MVQEDLEKTR AELKTAMSTP HVAEPAENEQ
   481  DEQDENGAEA SADLRADAMA KDRSEEERTT EAEKNERVQK HLKALTSELA NARDESKKTA
   541  NDMIHAENMR LGRDKYKTLR QIRQGNTKQR IDEFESM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
260 nTPM

Expression across tissuesHPA

Tissue

  • lung: 260 nTPM
  • blood vessel: 250 nTPM
  • appendix: 240 nTPM
  • smooth muscle: 229 nTPM
  • bone marrow: 225 nTPM
  • tonsil: 222 nTPM

Single-cell type

  • neutrophils: 901 nCPM
  • platelets: 881 nCPM
  • megakaryocytes: 544 nCPM
  • monocytes: 513 nCPM
  • neutrophil progenitors: 511 nCPM
  • alveolar cells type 1: 480 nCPM

Immune cell

  • total PBMC: 662 nTPM
  • non-classical monocyte: 450 nTPM
  • intermediate monocyte: 352 nTPM
  • neutrophil: 319 nTPM
  • classical monocyte: 306 nTPM
  • myeloid DC: 221 nTPM

Brain region

  • medulla oblongata: 128 nTPM
  • hypothalamus: 121 nTPM
  • white matter: 119 nTPM
  • spinal cord: 112 nTPM
  • thalamus: 107 nTPM
  • pons: 100 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MSN.

Disease | AllUniProt

Conditions MSN is implicated in, by any mechanism.

Disease | GeneticClinVar

18 pathogenic / likely-pathogenic of 347 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on MSN was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.13
gnomAD pLI
1
gnomAD missense Z
2.93
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MSN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSN as an antibody target. Whether an autoantibody or antibody against MSN could matter depends on whether native MSN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSN is annotated at the cell surface, where native MSN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MSN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MSN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...