Seroatlas · Human Serome Atlas

FCER1G

High affinity immunoglobulin epsilon receptor subunit gamma

Also known as: FcepsilonRIgamma, FCERG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P30273
Gene: FCER1G
Ensembl: ENSG00000158869
Chromosome: 1
Canonical length: 86 aa
Protein class: FDA approved drug targets, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

86 residues, UniProt reviewed canonical sequence.

>P30273|FCER1G
     1  MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV RKAAITSYEK
    61  SDGVYTGLST RNQETYETLK HEKPPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FCER1G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 449 nTPM

Expression across tissuesHPA

Tissue

spleen: 449 nTPM
bone marrow: 417 nTPM
lung: 270 nTPM
appendix: 260 nTPM
choroid plexus: 248 nTPM
urinary bladder: 237 nTPM

Single-cell type

neutrophils: 3,045 nCPM
hofbauer cells: 2,845 nCPM
kupffer cells: 2,554 nCPM
monocytes: 1,401 nCPM
megakaryocytes: 1,317 nCPM
cdc: 1,062 nCPM

Immune cell

non-classical monocyte: 7,025 nTPM
intermediate monocyte: 5,346 nTPM
total PBMC: 4,271 nTPM
plasmacytoid DC: 3,324 nTPM
classical monocyte: 3,251 nTPM
myeloid DC: 2,391 nTPM

Brain region

white matter: 83 nTPM
medulla oblongata: 59 nTPM
pons: 52 nTPM
thalamus: 52 nTPM
choroid plexus: 47 nTPM
hypothalamus: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.66
gnomAD missense Z: -0.02
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Phosphorylated immunoreceptor signalling ITAM
T-cell surface glycoprotein CD3 zeta subunit/High affinity IgE receptor gamma subunit
Immunoreceptor tyrosine-based activation motif
T-cell surface glycoprotein CD3 zeta chain
High affinity immunoglobulin epsilon receptor subunit gamma

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FCER1G in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FCER1G as an antibody target. Whether an autoantibody or antibody against FCER1G could matter depends on whether native FCER1G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FCER1G is annotated at the cell surface, where native FCER1G is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FCER1G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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