Seroatlas · Human Serome Atlas

GCSAM

Germinal center-associated signaling and motility protein

Also known as: GCET2, GCSAM_HUMAN, HGAL, MGC40441

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6F7
Gene: GCSAM
Ensembl: ENSG00000174500
Chromosome: 3
Canonical length: 178 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

178 residues, UniProt reviewed canonical sequence.

>Q8N6F7|GCSAM
     1  MGNSLLRENR RQQNTQEMPW NVRMQSPKQR TSRCWDHHIA EGCFCLPWKK ILIFEKRQDS
    61  QNENERMSST PIQDNVDQTY SEELCYTLIN HRVLCTRPSG NSAEEYYENV PCKAERPRES
   121  LGGTETEYSL LHMPSTDPRH ARSPEDEYEL LMPHRISSHF LQQPRPLMAP SETQFSHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GCSAM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

tonsil: 27 nTPM
lymph node: 21 nTPM
thymus: 17 nTPM
skin: 16 nTPM
appendix: 6.1 nTPM
spleen: 4.7 nTPM

Single-cell type

renal collecting duct principal cells: 3.3 nCPM
cdc: 2.1 nCPM
pdcs: 1.9 nCPM
t-cells: 1.2 nCPM
b-cells: 1 nCPM
kupffer cells: 1 nCPM

Immune cell

naive B-cell: 12 nTPM
memory CD4 T-cell: 11 nTPM
naive CD4 T-cell: 10 nTPM
memory B-cell: 10 nTPM
basophil: 9 nTPM
myeloid DC: 6.7 nTPM

Brain region

choroid plexus: 1 nTPM
cerebral cortex: 0.7 nTPM
midbrain: 0.7 nTPM
basal ganglia: 0.6 nTPM
hypothalamus: 0.6 nTPM
thalamus: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.06
gnomAD missense Z: 0.49
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GCSAM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GCSAM as an antibody target. Whether an autoantibody or antibody against GCSAM could matter depends on whether native GCSAM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GCSAM is annotated at the cell surface, where native GCSAM is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GCSAM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...