Seroatlas · Human Serome Atlas

TENT5A

Terminal nucleotidyltransferase 5A

Also known as: C6orf37, FAM46A, FLJ20037, TET5A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96IP4
Gene
TENT5A
Ensembl
ENSG00000112773
Chromosome
6
Canonical length
442 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables poly(A) RNA polymerase activity. Predicted to be involved in mRNA stabilization; positive regulation of bone mineralization; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within response to bacterium. Predicted to be located in cytoplasm. Implicated in lung non-small cell carcinoma; osteoarthritis; and osteogenesis imperfecta type 18. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

442 residues, UniProt reviewed canonical sequence.

>Q96IP4|TENT5A
     1  MAEGEGYFAM SEDELACSPY IPLGGDFGGG DFGGGDFGGG DFGGGGSFGG HCLDYCESPT
    61  AHCNVLNWEQ VQRLDGILSE TIPIHGRGNF PTLELQPSLI VKVVRRRLAE KRIGVRDVRL
   121  NGSAASHVLH QDSGLGYKDL DLIFCADLRG EGEFQTVKDV VLDCLLDFLP EGVNKEKITP
   181  LTLKEAYVQK MVKVCNDSDR WSLISLSNNS GKNVELKFVD SLRRQFEFSV DSFQIKLDSL
   241  LLFYECSENP MTETFHPTII GESVYGDFQE AFDHLCNKII ATRNPEEIRG GGLLKYCNLL
   301  VRGFRPASDE IKTLQRYMCS RFFIDFSDIG EQQRKLESYL QNHFVGLEDR KYEYLMTLHG
   361  VVNESTVCLM GHERRQTLNL ITMLAIRVLA DQNVIPNVAN VTCYYQPAPY VADANFSNYY
   421  IAQVQPVFTC QQQTYSTWLP CN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TENT5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
213 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 213 nTPM
  • salivary gland: 98 nTPM
  • stomach: 36 nTPM
  • liver: 34 nTPM
  • gallbladder: 30 nTPM
  • ovary: 26 nTPM

Single-cell type

  • lacrimal acinar cells: 631 nCPM
  • neutrophil progenitors: 508 nCPM
  • mast cells: 380 nCPM
  • foveolar cells: 377 nCPM
  • cardiomyocytes: 363 nCPM
  • enterocytes: 345 nCPM

Immune cell

  • non-classical monocyte: 48 nTPM
  • eosinophil: 47 nTPM
  • basophil: 38 nTPM
  • classical monocyte: 30 nTPM
  • intermediate monocyte: 30 nTPM
  • myeloid DC: 24 nTPM

Brain region

  • hypothalamus: 26 nTPM
  • choroid plexus: 17 nTPM
  • cerebellum: 15 nTPM
  • medulla oblongata: 13 nTPM
  • midbrain: 11 nTPM
  • thalamus: 9.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TENT5A.

Disease | AllUniProt

Conditions TENT5A is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 192 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Osteogenesis imperfecta, type 18
  • Esophageal atresia
  • Pyloric stenosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.92
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TENT5A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TENT5A as an antibody target. Whether an autoantibody or antibody against TENT5A could matter depends on whether native TENT5A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TENT5A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TENT5A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TENT5A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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