STK3
Serine/threonine-protein kinase 3
Also known as: KRS1, MST2, STK3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q13188
- Gene
- STK3
- Ensembl
- ENSG00000104375
- Chromosome
- 8
- Canonical length
- 491 aa
- Protein class
- Enzymes, Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Intermediate filaments,Rods & Rings
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Canonical amino-acid sequenceUniProt
491 residues, UniProt reviewed canonical sequence.
>Q13188|STK3
1 MEQPPAPKSK LKKLSEDSLT KQPEEVFDVL EKLGEGSYGS VFKAIHKESG QVVAIKQVPV
61 ESDLQEIIKE ISIMQQCDSP YVVKYYGSYF KNTDLWIVME YCGAGSVSDI IRLRNKTLIE
121 DEIATILKST LKGLEYLHFM RKIHRDIKAG NILLNTEGHA KLADFGVAGQ LTDTMAKRNT
181 VIGTPFWMAP EVIQEIGYNC VADIWSLGIT SIEMAEGKPP YADIHPMRAI FMIPTNPPPT
241 FRKPELWSDD FTDFVKKCLV KNPEQRATAT QLLQHPFIKN AKPVSILRDL ITEAMEIKAK
301 RHEEQQRELE EEEENSDEDE LDSHTMVKTS VESVGTMRAT STMSEGAQTM IEHNSTMLES
361 DLGTMVINSE DEEEEDGTMK RNATSPQVQR PSFMDYFDKQ DFKNKSHENC NQNMHEPFPM
421 SKNVFPDNWK VPQDGDFDFL KNLSLEELQM RLKALDPMME REIEELRQRY TAKRQPILDA
481 MDAKKRRQQN FLocalizationUniProt · AlphaFold · HPA
Whether an antibody against STK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 23 nTPM
Expression across tissuesHPA
Tissue
- endometrium: 23 nTPM
- ovary: 20 nTPM
- placenta: 17 nTPM
- fallopian tube: 17 nTPM
- seminal vesicle: 17 nTPM
- smooth muscle: 16 nTPM
Single-cell type
- leydig cells: 751 nCPM
- myonuclei: 703 nCPM
- renal collecting duct intercalated cells: 630 nCPM
- endometrial stromal cells: 538 nCPM
- fibro-adipogenic progenitors: 537 nCPM
- breast lactating cells: 525 nCPM
Immune cell
- neutrophil: 8.8 nTPM
- intermediate monocyte: 8.4 nTPM
- classical monocyte: 8.1 nTPM
- myeloid DC: 7.8 nTPM
- non-classical monocyte: 5.3 nTPM
- eosinophil: 4.5 nTPM
Brain region
- medulla oblongata: 11 nTPM
- white matter: 11 nTPM
- thalamus: 10 nTPM
- choroid plexus: 9.6 nTPM
- basal ganglia: 9.1 nTPM
- midbrain: 8.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.87
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.58
- DepMap mean gene effect
- -0.18
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 16% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- apoptotic process
- canonical Wnt signaling pathway
- cell differentiation involved in embryonic placenta development
- central nervous system development
- endocardium development
- epithelial cell proliferation
- extrinsic apoptotic signaling pathway via death domain receptors
- hepatocyte apoptotic process
- hippo signaling
- intracellular signal transduction
- JNK cascade
- negative regulation of canonical Wnt signaling pathway
- negative regulation of cell growth involved in contact inhibition
- negative regulation of epithelial cell proliferation
- negative regulation of organ growth
- neural tube formation
- organ growth
- phosphatidylinositol 3-kinase/protein kinase B signal transduction
- positive regulation of apoptotic process
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
- positive regulation of fat cell differentiation
- positive regulation of hippo signaling
- positive regulation of JNK cascade
- positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- primitive hemopoiesis
- protein import into nucleus
- protein localization to centrosome
- protein phosphorylation
- protein stabilization
- protein tetramerization
- regulation of cell differentiation involved in embryonic placenta development
- regulation of MAPK cascade
Molecular functions
- ATP binding
- identical protein binding
- magnesium ion binding
- protein kinase activity
- protein serine kinase activity
- protein serine/threonine kinase activator activity
- protein serine/threonine kinase activity
- transcription regulator activator activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of STK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads STK3 as an antibody target. Whether an autoantibody or antibody against STK3 could matter depends on whether native STK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
STK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label STK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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