Seroatlas · Human Serome Atlas

MOB1A

MOB kinase activator 1A

Also known as: C2orf6, FLJ10788, FLJ11595, Mats1, MOB1, MOB1A_HUMAN, Mob4B, MOBK1B, MOBKL1B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8S9
Gene: MOB1A
Ensembl: ENSG00000114978
Chromosome: 2
Canonical length: 216 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>Q9H8S9|MOB1A
     1  MSFLFSSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRQAVMLPEG EDLNEWIAVN
    61  TVDFFNQINM LYGTITEFCT EASCPVMSAG PRYEYHWADG TNIKKPIKCS APKYIDYLMT
   121  WVQDQLDDET LFPSKIGVPF PKNFMSVAKT ILKRLFRVYA HIYHQHFDSV MQLQEEAHLN
   181  TSFKHFIFFV QEFNLIDRRE LAPLQELIEK LGSKDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOB1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 87 nTPM

Expression across tissuesHPA

Tissue

tonsil: 87 nTPM
lymph node: 86 nTPM
bone marrow: 85 nTPM
appendix: 61 nTPM
spleen: 58 nTPM
thymus: 52 nTPM

Single-cell type

platelets: 782 nCPM
neutrophils: 423 nCPM
esophageal apical cells: 333 nCPM
monocytes: 285 nCPM
kupffer cells: 225 nCPM
neutrophil progenitors: 219 nCPM

Immune cell

non-classical monocyte: 127 nTPM
intermediate monocyte: 106 nTPM
basophil: 104 nTPM
eosinophil: 92 nTPM
total PBMC: 80 nTPM
neutrophil: 66 nTPM

Brain region

choroid plexus: 33 nTPM
white matter: 31 nTPM
medulla oblongata: 29 nTPM
spinal cord: 28 nTPM
hypothalamus: 27 nTPM
pons: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.95
gnomAD missense Z: 1.65
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

hippo signaling

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MOB1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOB1A as an antibody target. Whether an autoantibody or antibody against MOB1A could matter depends on whether native MOB1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOB1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOB1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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