RASSF4

Protein identityUniProt · HPA

UniProt accession

Q9H2L5

Gene

RASSF4

Ensembl

ENSG00000107551

Chromosome

10

Canonical length

321 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Cell Junctions,Cytokinetic bridge,Mitotic spindle,Cytosol

OverviewNCBI Gene

The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q9H2L5|RASSF4
     1  MKEDCLPSSH VPISDSKSIQ KSELLGLLKT YNCYHEGKSF QLRHREEEGT LIIEGLLNIA
    61  WGLRRPIRLQ MQDDREQVHL PSTSWMPRRP SCPLKEPSPQ NGNITAQGPS IQPVHKAESS
   121  TDSSGPLEEA EEAPQLMRTK SDASCMSQRR PKCRAPGEAQ RIRRHRFSIN GHFYNHKTSV
   181  FTPAYGSVTN VRVNSTMTTL QVLTLLLNKF RVEDGPSEFA LYIVHESGER TKLKDCEYPL
   241  ISRILHGPCE KIARIFLMEA DLGVEVPHEV AQYIKFEMPV LDSFVEKLKE EEEREIIKLT
   301  MKFQALRLTM LQRLEQLVEA K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASSF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

77 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.55

gnomAD pLI

0

gnomAD missense Z

0.14

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• signal transduction

Protein domainsUniProt · Pfam · InterPro

• Ras-associating domain
• SARAH domain
• Ubiquitin-like domain superfamily
• Ras association domain-containing protein 1-6
• Ras association (RalGDS/AF-6) domain
• Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
• Ras association domain-containing protein 4, RA domain

KeywordsUniProt

• Cell cycle
• Phosphoprotein
• Tumor suppressor

InteractionsUniProt · HPA

Protein binding partners of RASSF4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• STK3
• STK4