Seroatlas · Human Serome Atlas

RASSF6

Ras association domain-containing protein 6

Also known as: RASF6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZTQ3
Gene
RASSF6
Ensembl
ENSG00000169435
Chromosome
4
Canonical length
369 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>Q6ZTQ3|RASSF6
     1  MLWEETGAAP APARASDLPY RISSDHLKKE EKMTMMAHQY PSWIFINEKT FITREQLNSL
    61  LKTYNIFYEN QKNLHILYGE TEDGKLIVEG MLDIFWGVKR PIQLKIQDEK PFSSFTSMKS
   121  SDVFSSKGMT RWGEFDDLYR ISELDRTQIP MSEKRNSQED YLSYHSNTLK PHAKDEPDSP
   181  VLYRTMSEAA LVRKRMKPLM MDRKERQKNR ASINGHFYNH ETSIFIPAFE SETKVRVNSN
   241  MRTEEVIKQL LQKFKIENSP QDFALHIIFA TGEQRRLKKT DIPLLQRLLQ GPSEKNARIF
   301  LMDKDAEEIS SDVAQYINFH FSLLESILQR LNEEEKREIQ RIVTKFNKEK AIILKCLQNK
   361  LVIKTETTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASSF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 33 nTPM
  • thymus: 29 nTPM
  • pancreas: 16 nTPM
  • rectum: 12 nTPM
  • small intestine: 12 nTPM
  • colon: 11 nTPM

Single-cell type

  • tuft cells: 1,015 nCPM
  • foveolar cells: 422 nCPM
  • respiratory basal cells: 327 nCPM
  • respiratory ionocytes: 307 nCPM
  • breast lactating cells: 250 nCPM
  • prostatic hillock cells: 246 nCPM

Immune cell

  • memory B-cell: 2.7 nTPM
  • naive B-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • choroid plexus: 11 nTPM
  • midbrain: 2.2 nTPM
  • hypothalamus: 2 nTPM
  • cerebral cortex: 1 nTPM
  • hippocampal formation: 0.8 nTPM
  • medulla oblongata: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.93
gnomAD pLI
0
gnomAD missense Z
-1.19
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RASSF6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASSF6 as an antibody target. Whether an autoantibody or antibody against RASSF6 could matter depends on whether native RASSF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASSF6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RASSF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RASSF6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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