Seroatlas · Human Serome Atlas

MOB1B

MOB kinase activator 1B

Also known as: MOB1B_HUMAN, MOB4A, MOBKL1A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L9L4
Gene: MOB1B
Ensembl: ENSG00000173542
Chromosome: 4
Canonical length: 216 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>Q7L9L4|MOB1B
     1  MSFLFGSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRMAVMLPEG EDLNEWVAVN
    61  TVDFFNQINM LYGTITDFCT EESCPVMSAG PKYEYHWADG TNIKKPIKCS APKYIDYLMT
   121  WVQDQLDDET LFPSKIGVPF PKNFMSVAKT ILKRLFRVYA HIYHQHFDPV IQLQEEAHLN
   181  TSFKHFIFFV QEFNLIDRRE LAPLQELIEK LTSKDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOB1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 28 nTPM
kidney: 21 nTPM
thymus: 19 nTPM
parathyroid gland: 12 nTPM
lymph node: 11 nTPM
cerebral cortex: 10 nTPM

Single-cell type

renal collecting duct intercalated cells: 687 nCPM
platelets: 651 nCPM
choroid plexus epithelial cells: 443 nCPM
renal collecting duct principal cells: 329 nCPM
ependymal cells: 307 nCPM
renal connecting tubule cells: 283 nCPM

Immune cell

plasmacytoid DC: 2.1 nTPM
myeloid DC: 1.7 nTPM
classical monocyte: 1.2 nTPM
eosinophil: 1.1 nTPM
intermediate monocyte: 0.6 nTPM
T-reg: 0.6 nTPM

Brain region

choroid plexus: 49 nTPM
hippocampal formation: 48 nTPM
white matter: 40 nTPM
hypothalamus: 38 nTPM
spinal cord: 36 nTPM
cerebral cortex: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0.04
gnomAD missense Z: 0.43
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MOB1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOB1B as an antibody target. Whether an autoantibody or antibody against MOB1B could matter depends on whether native MOB1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOB1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOB1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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