Seroatlas · Human Serome Atlas

SLMAP

Sarcolemmal membrane-associated protein

Also known as: KIAA1601, SLAP, SLMAP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14BN4
Gene
SLMAP
Ensembl
ENSG00000163681
Chromosome
3
Canonical length
828 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

828 residues, UniProt reviewed canonical sequence.

>Q14BN4|SLMAP
     1  MPSALAIFTC RPNSHPFQER HVYLDEPIKI GRSVARCRPA QNNATFDCKV LSRNHALVWF
    61  DHKTGKFYLQ DTKSSNGTFI NSQRLSRGSE ESPPCEILSG DIIQFGVDVT ENTRKVTHGC
   121  IVSTIKLFLP DGMEARLRSD VIHAPLPSPV DKVAANTPSM YSQELFQLSQ YLQEALHREQ
   181  MLEQKLATLQ RLLAITQEAS DTSWQALIDE DRLLSRLEVM GNQLQACSKN QTEDSLRKEL
   241  IALQEDKHNY ETTAKESLRR VLQEKIEVVR KLSEVERSLS NTEDECTHLK EMNERTQEEL
   301  RELANKYNGA VNEIKDLSDK LKVAEGKQEE IQQKGQAEKK ELQHKIDEME EKEQELQAKI
   361  EALQADNDFT NERLTALQVR LEHLQEKTLK ECSSLEHLLS KSGGDCTFIH QFIECQKKLI
   421  VEGHLTKAVE ETKLSKENQT RAKESDFSDT LSPSKEKSSD DTTDAQMDEQ DLNEPLAKVS
   481  LLKDDLQGAQ SEIEAKQEIQ HLRKELIEAQ ELARTSKQKC FELQALLEEE RKAYRNQVEE
   541  STKQIQVLQA QLQRLHIDTE NLREEKDSEI TSTRDELLSA RDEILLLHQA AAKVASERDT
   601  DIASLQEELK KVRAELERWR KAASEYEKEI TSLQNSFQLR CQQCEDQQRE EATRLQGELE
   661  KLRKEWNALE TECHSLKREN VLLSSELQRQ EKELHNSQKQ SLELTSDLSI LQMSRKELEN
   721  QVGSLKEQHL RDSADLKTLL SKAENQAKDV QKEYEKTQTV LSELKLKFEM TEQEKQSITD
   781  ELKQCKNNLK LLREKGNNKP WPWMPMLAAL VAVTAIVLYV PGLARASP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLMAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
101 nTPM

Expression across tissuesHPA

Tissue

  • smooth muscle: 101 nTPM
  • colon: 87 nTPM
  • heart muscle: 81 nTPM
  • esophagus: 73 nTPM
  • seminal vesicle: 71 nTPM
  • blood vessel: 69 nTPM

Single-cell type

  • smooth muscle cells: 910 nCPM
  • neutrophils: 772 nCPM
  • myonuclei: 638 nCPM
  • ocular epithelial cells: 583 nCPM
  • basal keratinocytes: 529 nCPM
  • endometrial luminal cells: 494 nCPM

Immune cell

  • eosinophil: 11 nTPM
  • neutrophil: 9.5 nTPM
  • NK-cell: 4.9 nTPM
  • T-reg: 4.1 nTPM
  • basophil: 4 nTPM
  • memory B-cell: 3.8 nTPM

Brain region

  • basal ganglia: 33 nTPM
  • choroid plexus: 26 nTPM
  • cerebellum: 25 nTPM
  • thalamus: 22 nTPM
  • midbrain: 20 nTPM
  • amygdala: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
1
gnomAD missense Z
1.7
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLMAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLMAP as an antibody target. Whether an autoantibody or antibody against SLMAP could matter depends on whether native SLMAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLMAP is annotated at the cell surface, where native SLMAP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLMAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLMAP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...