Seroatlas · Human Serome Atlas

RASSF3

Ras association domain-containing protein 3

Also known as: RASF3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WH2
Gene: RASSF3
Ensembl: ENSG00000153179
Chromosome: 12
Canonical length: 238 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.[supplied by OMIM, Jul 2003]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>Q86WH2|RASSF3
     1  MSSGYSSLEE DAEDFFFTAR TSFFRRAPQG KPRSGQQDVE KEKETHSYLS KEEIKEKVHK
    61  YNLAVTDKLK MTLNSNGIYT GFIKVQMELC KPPQTSPNSG KLSPSSNGCM NTLHISSTNT
   121  VGEVIEALLK KFLVTESPAK FALYKRCHRE DQVYACKLSD REHPLYLRLV AGPRTDTLSF
   181  VLREHEIGEW EAFSLPELQN FLRILDKEED EQLQNLKRRY TAYRQKLEEA LREVWKPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASSF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 137 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 137 nTPM
colon: 98 nTPM
smooth muscle: 56 nTPM
seminal vesicle: 46 nTPM
spleen: 45 nTPM
skeletal muscle: 42 nTPM

Single-cell type

neutrophils: 1,471 nCPM
monocytes: 463 nCPM
cdc: 283 nCPM
neutrophil progenitors: 251 nCPM
endometrial glandular cells: 234 nCPM
choroid plexus epithelial cells: 222 nCPM

Immune cell

neutrophil: 125 nTPM
T-reg: 22 nTPM
naive CD8 T-cell: 20 nTPM
basophil: 20 nTPM
memory CD4 T-cell: 19 nTPM
naive CD4 T-cell: 19 nTPM

Brain region

choroid plexus: 70 nTPM
thalamus: 46 nTPM
midbrain: 44 nTPM
amygdala: 29 nTPM
medulla oblongata: 28 nTPM
white matter: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RASSF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASSF3 as an antibody target. Whether an autoantibody or antibody against RASSF3 could matter depends on whether native RASSF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASSF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RASSF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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