Seroatlas · Human Serome Atlas

SAV1

Protein salvador homolog 1

Also known as: salvador, SAV1_HUMAN, WW45, WWP4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H4B6
Gene
SAV1
Ensembl
ENSG00000151748
Chromosome
14
Canonical length
383 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

383 residues, UniProt reviewed canonical sequence.

>Q9H4B6|SAV1
     1  MLSRKKTKNE VSKPAEVQGK YVKKETSPLL RNLMPSFIRH GPTIPRRTDI CLPDSSPNAF
    61  STSGDVVSRN QSFLRTPIQR TPHEIMRRES NRLSAPSYLA RSLADVPREY GSSQSFVTEV
   121  SFAVENGDSG SRYYYSDNFF DGQRKRPLGD RAHEDYRYYE YNHDLFQRMP QNQGRHASGI
   181  GRVAATSLGN LTNHGSEDLP LPPGWSVDWT MRGRKYYIDH NTNTTHWSHP LEREGLPPGW
   241  ERVESSEFGT YYVDHTNKKA QYRHPCAPSV PRYDQPPPVT YQPQQTERNQ SLLVPANPYH
   301  TAEIPDWLQV YARAPVKYDH ILKWELFQLA DLDTYQGMLK LLFMKELEQI VKMYEAYRQA
   361  LLTELENRKQ RQQWYAQQHG KNF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAV1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 42 nTPM
  • breast: 33 nTPM
  • pancreas: 32 nTPM
  • thyroid gland: 32 nTPM
  • ovary: 30 nTPM
  • blood vessel: 30 nTPM

Single-cell type

  • platelets: 230 nCPM
  • prostatic glandular cells: 171 nCPM
  • salivary acinar cells: 164 nCPM
  • epididymal clear cells: 163 nCPM
  • pancreatic acinar cells: 142 nCPM
  • lacrimal acinar cells: 118 nCPM

Immune cell

  • naive B-cell: 3.4 nTPM
  • memory B-cell: 3.3 nTPM
  • plasmacytoid DC: 1.2 nTPM
  • T-reg: 1 nTPM
  • MAIT T-cell: 0.9 nTPM
  • gdT-cell: 0.8 nTPM

Brain region

  • choroid plexus: 41 nTPM
  • white matter: 34 nTPM
  • thalamus: 30 nTPM
  • medulla oblongata: 30 nTPM
  • basal ganglia: 29 nTPM
  • pons: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
gnomAD missense Z
-0.68
DepMap mean gene effect
0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAV1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAV1 as an antibody target. Whether an autoantibody or antibody against SAV1 could matter depends on whether native SAV1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAV1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAV1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SAV1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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