Seroatlas · Human Serome Atlas

MTERF3

Transcription termination factor 3, mitochondrial

Also known as: CGI-12, FLJ10939, MTEF3_HUMAN, MTERFD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96E29
Gene: MTERF3
Ensembl: ENSG00000156469
Chromosome: 8
Canonical length: 417 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

Enables transcription cis-regulatory region binding activity. Involved in negative regulation of DNA-templated transcription. Located in cytosol and mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>Q96E29|MTERF3
     1  MALSAQQIPR WFNSVKLRSL INAAQLTKRF TRPARTLLHG FSAQPQISSD NCFLQWGFKT
    61  YRTSSLWNSS QSTSSSSQEN NSAQSSLLPS MNEQSQKTQN ISSFDSELFL EELDELPPLS
   121  PMQPISEEEA IQIIADPPLP PASFTLRDYV DHSETLQKLV LLGVDLSKIE KHPEAANLLL
   181  RLDFEKDIKQ MLLFLKDVGI EDNQLGAFLT KNHAIFSEDL ENLKTRVAYL HSKNFSKADV
   241  AQMVRKAPFL LNFSVERLDN RLGFFQKELE LSVKKTRDLV VRLPRLLTGS LEPVKENMKV
   301  YRLELGFKHN EIQHMITRIP KMLTANKMKL TETFDFVHNV MSIPHHIIVK FPQVFNTRLF
   361  KVKERHLFLT YLGRAQYDPA KPNYISLDKL VSIPDEIFCE EIAKASVQDF EKFLKTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTERF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

tongue: 36 nTPM
skeletal muscle: 28 nTPM
heart muscle: 26 nTPM
liver: 22 nTPM
choroid plexus: 22 nTPM
epididymis: 22 nTPM

Single-cell type

oocytes: 120 nCPM
cardiomyocytes: 47 nCPM
cytotrophoblasts: 41 nCPM
differentiating spermatogonia: 35 nCPM
migrating cytotrophoblasts: 33 nCPM
erythrocyte progenitors: 32 nCPM

Immune cell

basophil: 39 nTPM
plasmacytoid DC: 24 nTPM
NK-cell: 24 nTPM
MAIT T-cell: 23 nTPM
memory B-cell: 21 nTPM
myeloid DC: 20 nTPM

Brain region

choroid plexus: 24 nTPM
cerebellum: 19 nTPM
white matter: 17 nTPM
hypothalamus: 16 nTPM
cerebral cortex: 16 nTPM
pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 19% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription cis-regulatory region binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTERF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RNF157

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTERF3 as an antibody target. Whether an autoantibody or antibody against MTERF3 could matter depends on whether native MTERF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTERF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTERF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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