Seroatlas · Human Serome Atlas

TXNDC5

Thioredoxin domain-containing protein 5

Also known as: EndoPDI, ERp46, FLJ21353, FLJ90810, Hcc-2, MGC3178, PDIA15, TXND5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBS9
Gene: TXNDC5
Ensembl: ENSG00000239264
Chromosome: 6
Canonical length: 432 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>Q8NBS9|TXNDC5
     1  MPARPGRLLP LLARPAALTA LLLLLLGHGG GGRWGARAQE AAAAAADGPP AADGEDGQDP
    61  HSKHLYTADM FTHGIQSAAH FVMFFAPWCG HCQRLQPTWN DLGDKYNSME DAKVYVAKVD
   121  CTAHSDVCSA QGVRGYPTLK LFKPGQEAVK YQGPRDFQTL ENWMLQTLNE EPVTPEPEVE
   181  PPSAPELKQG LYELSASNFE LHVAQGDHFI KFFAPWCGHC KALAPTWEQL ALGLEHSETV
   241  KIGKVDCTQH YELCSGNQVR GYPTLLWFRD GKKVDQYKGK RDLESLREYV ESQLQRTETG
   301  ATETVTPSEA PVLAAEPEAD KGTVLALTEN NFDDTIAEGI TFIKFYAPWC GHCKTLAPTW
   361  EELSKKEFPG LAGVKIAEVD CTAERNICSK YSVRGYPTLL LFRGGKKVSE HSGGRDLDSL
   421  HRFVLSQAKD EL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TXNDC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 271 nTPM

Expression across tissuesHPA

Tissue

stomach: 271 nTPM
colon: 250 nTPM
duodenum: 248 nTPM
tonsil: 247 nTPM
spleen: 238 nTPM
salivary gland: 207 nTPM

Single-cell type

plasma cells: 131 nCPM
choroid plexus epithelial cells: 38 nCPM
goblet cells: 20 nCPM
parietal cells: 16 nCPM
microglia: 15 nCPM
b-cells: 15 nCPM

Immune cell

plasmacytoid DC: 27 nTPM
memory B-cell: 13 nTPM
naive B-cell: 6.9 nTPM
myeloid DC: 1 nTPM
gdT-cell: 0.9 nTPM
T-reg: 0.9 nTPM

Brain region

choroid plexus: 90 nTPM
thalamus: 36 nTPM
white matter: 32 nTPM
spinal cord: 32 nTPM
medulla oblongata: 32 nTPM
midbrain: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: -0.42
DepMap mean gene effect: 0.19
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TXNDC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RNF157

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TXNDC5 as an antibody target. Whether an autoantibody or antibody against TXNDC5 could matter depends on whether native TXNDC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TXNDC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TXNDC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...