Seroatlas · Human Serome Atlas

MRPL19

Large ribosomal subunit protein bL19m

Also known as: KIAA0104, MRP-L15, RLX1, RM19_HUMAN, RPML15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49406
Gene: MRPL19
Ensembl: ENSG00000115364
Chromosome: 2
Canonical length: 292 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>P49406|MRPL19
     1  MAACIAAGHW AAMGLGRSFQ AARTLLPPPA SIACRVHAGP VRQQSTGPSE PGAFQPPPKP
    61  VIVDKHRPVE PERRFLSPEF IPRRGRTDPL KFQIERKDML ERRKVLHIPE FYVGSILRVT
   121  TADPYASGKI SQFLGICIQR SGRGLGATFI LRNVIEGQGV EICFELYNPR VQEIQVVKLE
   181  KRLDDSLLYL RDALPEYSTF DVNMKPVVQE PNQKVPVNEL KVKMKPKPWS KRWERPNFNI
   241  KGIRFDLCLT EQQMKEAQKW NQPWLEFDMM REYDTSKIEA AIWKEIEASK RS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 62 nTPM
liver: 59 nTPM
kidney: 52 nTPM
parathyroid gland: 42 nTPM
tongue: 42 nTPM
thyroid gland: 35 nTPM

Single-cell type

myonuclei: 254 nCPM
oocytes: 138 nCPM
cardiomyocytes: 131 nCPM
cytotrophoblasts: 126 nCPM
esophageal suprabasal cells: 126 nCPM
migrating cytotrophoblasts: 119 nCPM

Immune cell

plasmacytoid DC: 35 nTPM
myeloid DC: 30 nTPM
memory B-cell: 27 nTPM
intermediate monocyte: 27 nTPM
T-reg: 27 nTPM
MAIT T-cell: 25 nTPM

Brain region

white matter: 76 nTPM
spinal cord: 66 nTPM
hypothalamus: 66 nTPM
basal ganglia: 66 nTPM
cerebellum: 66 nTPM
medulla oblongata: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0.03
gnomAD missense Z: 0.13
DepMap mean gene effect: -0.34
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial translation

Molecular functions

structural constituent of ribosome

Cellular components

Protein domainsUniProt · Pfam · InterPro

Translation protein SH3-like domain superfamily
Large ribosomal subunit protein bL19
Large ribosomal subunit protein bL19 superfamily
Ribosomal protein L19

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL19 as an antibody target. Whether an autoantibody or antibody against MRPL19 could matter depends on whether native MRPL19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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