Seroatlas · Human Serome Atlas

TECR

Very-long-chain enoyl-CoA reductase

Also known as: GPSN2, MRT14, SC2, TECR_HUMAN, TER

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZ01
Gene
TECR
Ensembl
ENSG00000099797
Chromosome
19
Canonical length
308 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>Q9NZ01|TECR
     1  MKHYEVEILD AKTREKLCFL DKVEPHATIA EIKNLFTKTH PQWYPARQSL RLDPKGKSLK
    61  DEDVLQKLPV GTTATLYFRD LGAQISWVTV FLTEYAGPLF IYLLFYFRVP FIYGHKYDFT
   121  SSRHTVVHLA CICHSFHYIK RLLETLFVHR FSHGTMPLRN IFKNCTYYWG FAAWMAYYIN
   181  HPLYTPPTYG AQQVKLALAI FVICQLGNFS IHMALRDLRP AGSKTRKIPY PTKNPFTWLF
   241  LLVSCPNYTY EVGSWIGFAI MTQCLPVALF SLVGFTQMTI WAKGKHRSYL KEFRDYPPLR
   301  MPIIPFLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TECR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
352 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 352 nTPM
  • skeletal muscle: 343 nTPM
  • choroid plexus: 332 nTPM
  • parathyroid gland: 288 nTPM
  • skin: 249 nTPM
  • spinal cord: 212 nTPM

Single-cell type

  • late spermatids: 1,462 nCPM
  • esophageal apical cells: 1,246 nCPM
  • esophageal suprabasal cells: 624 nCPM
  • extravillous trophoblasts: 499 nCPM
  • late primary spermatocytes: 432 nCPM
  • breast lactating cells: 410 nCPM

Immune cell

  • T-reg: 291 nTPM
  • naive CD4 T-cell: 208 nTPM
  • NK-cell: 184 nTPM
  • memory CD4 T-cell: 181 nTPM
  • total PBMC: 171 nTPM
  • naive CD8 T-cell: 165 nTPM

Brain region

  • white matter: 224 nTPM
  • cerebellum: 212 nTPM
  • choroid plexus: 204 nTPM
  • pons: 193 nTPM
  • medulla oblongata: 190 nTPM
  • spinal cord: 185 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TECR.

Disease | AllUniProt

Conditions TECR is implicated in, by any mechanism.

  • Intellectual developmental disorder, autosomal recessive 14 (MRT14) MIM:614020

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.11
gnomAD missense Z
1.78
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TECR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TECR as an antibody target. Whether an autoantibody or antibody against TECR could matter depends on whether native TECR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TECR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TECR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TECR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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