C1D

Protein identityUniProt · HPA

UniProt accession

Q13901

Gene

C1D

Ensembl

ENSG00000197223

Chromosome

2

Canonical length

141 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

141 residues, UniProt reviewed canonical sequence.

>Q13901|C1D
     1  MAGEEINEDY PVEIHEYLSA FENSIGAVDE MLKTMMSVSR NELLQKLDPL EQAKVDLVSA
    61  YTLNSMFWVY LATQGVNPKE HPVKQELERI RVYMNRVKEI TDKKKAGKLD RGAASRFVKN
   121  ALWEPKSKNA SKVANKGKSK S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

45 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for C1D from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.24

gnomAD pLI

0.03

gnomAD missense Z

0

DepMap mean gene effect

-0.4

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• maturation of 5.8S rRNA
• regulation of gene expression

Molecular functions

• DNA binding
• nuclear receptor binding
• RNA binding
• transcription corepressor activity

Cellular components

• cytoplasm
• exosome (RNase complex)
• nuclear exosome (RNase complex)
• nucleolus
• nucleoplasm
• nucleus
• transcription repressor complex

Protein domainsUniProt · Pfam · InterPro

• Sas10/Utp3/C1D
• Sas10/Utp3/C1D family
• Exosome-associated factor Rrp47/DNA strand repair C1D

KeywordsUniProt

• Apoptosis
• Cytoplasm
• DNA-binding
• Isopeptide bond
• Nucleus
• Phosphoprotein
• Repressor
• RNA-binding
• rRNA processing
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of C1D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EXOSC10
• NCOR1
• NCOR2
• NR1D1
• RAC3
• THRA
• THRB
• TSNAX
• PRKDC
• EXOSC1
• EXOSC5
• RBM7