Seroatlas · Human Serome Atlas

EXOSC3

Exosome complex component RRP40

Also known as: CGI-102, EXOS3_HUMAN, hRrp-40, hRrp40p, p10, RRP40, Rrp40p

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQT5
Gene
EXOSC3
Ensembl
ENSG00000107371
Chromosome
9
Canonical length
275 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>Q9NQT5|EXOSC3
     1  MAEPASVAAE SLAGSRARAA RTVLGQVVLP GEELLLPEQE DAEGPGGAVE RPLSLNARAC
    61  SRVRVVCGPG LRRCGDRLLV TKCGRLRHKE PGSGSGGGVY WVDSQQKRYV PVKGDHVIGI
   121  VTAKSGDIFK VDVGGSEPAS LSYLSFEGAT KRNRPNVQVG DLIYGQFVVA NKDMEPEMVC
   181  IDSCGRANGM GVIGQDGLLF KVTLGLIRKL LAPDCEIIQE VGKLYPLEIV FGMNGRIWVK
   241  AKTIQQTLIL ANILEACEHM TSDQRKQIFS RLAES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOSC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • testis: 20 nTPM
  • esophagus: 13 nTPM
  • thymus: 12 nTPM
  • tonsil: 11 nTPM
  • adrenal gland: 11 nTPM
  • lymph node: 11 nTPM

Single-cell type

  • early spermatids: 40 nCPM
  • oligodendrocytes: 38 nCPM
  • bergmann glia: 38 nCPM
  • astrocytes: 33 nCPM
  • brain excitatory neurons: 33 nCPM
  • oligodendrocyte progenitor cells: 32 nCPM

Immune cell

  • total PBMC: 56 nTPM
  • intermediate monocyte: 54 nTPM
  • memory B-cell: 54 nTPM
  • T-reg: 52 nTPM
  • plasmacytoid DC: 51 nTPM
  • non-classical monocyte: 50 nTPM

Brain region

  • cerebellum: 17 nTPM
  • white matter: 13 nTPM
  • cerebral cortex: 11 nTPM
  • spinal cord: 10 nTPM
  • choroid plexus: 10 nTPM
  • hypothalamus: 10 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EXOSC3.

Disease | AllUniProt

Conditions EXOSC3 is implicated in, by any mechanism.

Disease | GeneticClinVar

51 pathogenic / likely-pathogenic of 321 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.21
gnomAD pLI
0
gnomAD missense Z
-0.22
DepMap mean gene effect
-1.18
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EXOSC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EXOSC3 as an antibody target. Whether an autoantibody or antibody against EXOSC3 could matter depends on whether native EXOSC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EXOSC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EXOSC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EXOSC3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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