Seroatlas · Human Serome Atlas

MPHOSPH6

M-phase phosphoprotein 6

Also known as: MPH6_HUMAN, MPP6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99547
Gene: MPHOSPH6
Ensembl: ENSG00000135698
Chromosome: 16
Canonical length: 160 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable RNA binding activity. Involved in maturation of 5.8S rRNA. Located in cytosol and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>Q99547|MPHOSPH6
     1  MAAERKTRLS KNLLRMKFMQ RGLDSETKKQ LEEEEKKIIS EEHWYLDLPE LKEKESFIIE
    61  EQSFLLCEDL LYGRMSFRGF NPEVEKLMLQ MNAKHKAEEV EDETVELDVS DEEMARRYET
   121  LVGTIGKKFA RKRDHANYEE DENGDITPIK AKKMFLKPQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPHOSPH6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

breast: 68 nTPM
skin: 38 nTPM
esophagus: 35 nTPM
urinary bladder: 32 nTPM
retina: 29 nTPM
cerebral cortex: 28 nTPM

Single-cell type

breast lactating cells: 186 nCPM
esophageal suprabasal cells: 117 nCPM
breast hormone-responsive cells: 114 nCPM
esophageal basal cells: 112 nCPM
monocytes: 100 nCPM
differentiating spermatogonia: 85 nCPM

Immune cell

MAIT T-cell: 49 nTPM
intermediate monocyte: 47 nTPM
myeloid DC: 45 nTPM
T-reg: 44 nTPM
naive CD4 T-cell: 41 nTPM
memory CD8 T-cell: 40 nTPM

Brain region

cerebellum: 40 nTPM
hypothalamus: 38 nTPM
white matter: 37 nTPM
cerebral cortex: 36 nTPM
basal ganglia: 34 nTPM
midbrain: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -1.28
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

maturation of 5.8S rRNA

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

M-phase phosphoprotein 6
M-phase phosphoprotein 6

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MPHOSPH6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPHOSPH6 as an antibody target. Whether an autoantibody or antibody against MPHOSPH6 could matter depends on whether native MPHOSPH6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPHOSPH6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MPHOSPH6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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