Seroatlas · Human Serome Atlas

TBC1D13

TBC1 domain family member 13

Also known as: FLJ10743, TBC13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVG8
Gene: TBC1D13
Ensembl: ENSG00000107021
Chromosome: 9
Canonical length: 400 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Predicted to be involved in intracellular protein transport. Predicted to be located in cytosol and membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>Q9NVG8|TBC1D13
     1  MSSLHKSRIA DFQDVLKEPS IALEKLRELS FSGIPCEGGL RCLCWKILLN YLPLERASWT
    61  SILAKQRELY AQFLREMIIQ PGIAKANMGV SREDVTFEDH PLNPNPDSRW NTYFKDNEVL
   121  LQIDKDVRRL CPDISFFQRA TDYPCLLILD PQNEFETLRK RVEQTTLKSQ TVARNRSGVT
   181  NMSSPHKNSV PSSLNEYEVL PNGCEAHWEV VERILFIYAK LNPGIAYVQG MNEIVGPLYY
   241  TFATDPNSEW KEHAEADTFF CFTNLMAEIR DNFIKSLDDS QCGITYKMEK VYSTLKDKDV
   301  ELYLKLQEQN IKPQFFAFRW LTLLLSQEFL LPDVIRIWDS LFADDNRFDF LLLVCCAMLM
   361  LIREQLLEGD FTVNMRLLQD YPITDVCQIL QKAKELQDSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

amygdala: 32 nTPM
cerebral cortex: 32 nTPM
kidney: 28 nTPM
hippocampal formation: 28 nTPM
parathyroid gland: 27 nTPM
hypothalamus: 25 nTPM

Single-cell type

oligodendrocytes: 48 nCPM
proximal tubule cells: 42 nCPM
myonuclei: 40 nCPM
hofbauer cells: 36 nCPM
platelets: 30 nCPM
megakaryocytes: 25 nCPM

Immune cell

basophil: 23 nTPM
plasmacytoid DC: 8.4 nTPM
naive CD8 T-cell: 5 nTPM
eosinophil: 4.8 nTPM
memory B-cell: 4.7 nTPM
MAIT T-cell: 4.4 nTPM

Brain region

amygdala: 43 nTPM
cerebral cortex: 40 nTPM
pons: 38 nTPM
medulla oblongata: 38 nTPM
hypothalamus: 38 nTPM
white matter: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: 1.79
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular protein transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBC1D13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D13 as an antibody target. Whether an autoantibody or antibody against TBC1D13 could matter depends on whether native TBC1D13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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