Seroatlas · Human Serome Atlas

TM9SF4

Transmembrane 9 superfamily member 4

Also known as: dJ836N17.2, KIAA0255, TM9S4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92544
Gene: TM9SF4
Ensembl: ENSG00000101337
Chromosome: 20
Canonical length: 642 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Involved in several processes, including positive regulation of protein localization; regulation of intracellular pH; and vacuolar proton-transporting V-type ATPase complex assembly. Located in Golgi apparatus and early endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

642 residues, UniProt reviewed canonical sequence.

>Q92544|TM9SF4
     1  MATAMDWLPW SLLLFSLMCE TSAFYVPGVA PINFHQNDPV EIKAVKLTSS RTQLPYEYYS
    61  LPFCQPSKIT YKAENLGEVL RGDRIVNTPF QVLMNSEKKC EVLCSQSNKP VTLTVEQSRL
   121  VAERITEDYY VHLIADNLPV ATRLELYSNR DSDDKKKEKD VQFEHGYRLG FTDVNKIYLH
   181  NHLSFILYYH REDMEEDQEH TYRVVRFEVI PQSIRLEDLK ADEKSSCTLP EGTNSSPQEI
   241  DPTKENQLYF TYSVHWEESD IKWASRWDTY LTMSDVQIHW FSIINSVVVV FFLSGILSMI
   301  IIRTLRKDIA NYNKEDDIED TMEESGWKLV HGDVFRPPQY PMILSSLLGS GIQLFCMILI
   361  VIFVAMLGML SPSSRGALMT TACFLFMFMG VFGGFSAGRL YRTLKGHRWK KGAFCTATLY
   421  PGVVFGICFV LNCFIWGKHS SGAVPFPTMV ALLCMWFGIS LPLVYLGYYF GFRKQPYDNP
   481  VRTNQIPRQI PEQRWYMNRF VGILMAGILP FGAMFIELFF IFSAIWENQF YYLFGFLFLV
   541  FIILVVSCSQ ISIVMVYFQL CAEDYRWWWR NFLVSGGSAF YVLVYAIFYF VNKLDIVEFI
   601  PSLLYFGYTA LMVLSFWLLT GTIGFYAAYM FVRKIYAAVK ID

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TM9SF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 50 nTPM
placenta: 37 nTPM
rectum: 35 nTPM
fallopian tube: 33 nTPM
esophagus: 32 nTPM
liver: 32 nTPM

Single-cell type

neutrophils: 116 nCPM
monocytes: 91 nCPM
late spermatids: 90 nCPM
myonuclei: 88 nCPM
esophageal apical cells: 86 nCPM
choroid plexus epithelial cells: 83 nCPM

Immune cell

non-classical monocyte: 68 nTPM
intermediate monocyte: 51 nTPM
classical monocyte: 48 nTPM
myeloid DC: 42 nTPM
total PBMC: 35 nTPM
MAIT T-cell: 25 nTPM

Brain region

choroid plexus: 49 nTPM
hypothalamus: 45 nTPM
cerebral cortex: 43 nTPM
thalamus: 40 nTPM
pons: 40 nTPM
basal ganglia: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 2.96
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TM9SF4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TM9SF4 as an antibody target. Whether an autoantibody or antibody against TM9SF4 could matter depends on whether native TM9SF4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TM9SF4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TM9SF4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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