Seroatlas · Human Serome Atlas

RABIF

Guanine nucleotide exchange factor MSS4

Also known as: mss4, MSS4_HUMAN, RASGRF3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P47224
Gene: RABIF
Ensembl: ENSG00000183155
Chromosome: 1
Canonical length: 123 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge

OverviewNCBI Gene

This gene encodes a member of the SCE4/YPT1/RAB family of small GTP-binding proteins that are involved in the regulation of intracellular vesicular transport. This protein stimulates GTP-GDP exchange in SEC4, and to a lesser extent in YPT1 and RAB3A, and may play a general role in vesicular transport. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>P47224|RABIF
     1  MEPAEQPSEL VSAEGRNRKA VLCQRCGSRV LQPGTALFSR RQLFLPSMRK KPALSDGSNP
    61  DGDLLQEHWL VEDMFIFENV GFTKDVGNIK FLVCADCEIG PIGWHCLDDK NSFYVALERV
   121  SHE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RABIF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
spinal cord: 9.1 nTPM
cerebral cortex: 8.2 nTPM
tonsil: 8 nTPM
bone marrow: 7.9 nTPM
hypothalamus: 7 nTPM

Single-cell type

late spermatids: 5,435 nCPM
early spermatids: 766 nCPM
esophageal apical cells: 305 nCPM
late primary spermatocytes: 213 nCPM
esophageal suprabasal cells: 113 nCPM
syncytiotrophoblasts: 105 nCPM

Immune cell

neutrophil: 33 nTPM
basophil: 33 nTPM
eosinophil: 32 nTPM
intermediate monocyte: 23 nTPM
non-classical monocyte: 22 nTPM
classical monocyte: 21 nTPM

Brain region

cerebral cortex: 12 nTPM
white matter: 11 nTPM
hypothalamus: 11 nTPM
basal ganglia: 11 nTPM
midbrain: 10 nTPM
pons: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0.01
gnomAD missense Z: -0.07
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Mss4-like superfamily
Mss4/translationally controlled tumour-associated TCTP
Mss4
Mss4 protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RABIF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RABIF as an antibody target. Whether an autoantibody or antibody against RABIF could matter depends on whether native RABIF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RABIF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RABIF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...