Seroatlas · Human Serome Atlas

GOLGA5

Golgin subfamily A member 5

Also known as: GOGA5_HUMAN, golgin-84, GOLIM5, ret-II, rfg5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TBA6
Gene
GOLGA5
Ensembl
ENSG00000066455
Chromosome
14
Canonical length
731 aa
Protein class
Cancer-related genes, Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus
Quaternary structure
Homodimer

OverviewNCBI Gene

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

731 residues, UniProt reviewed canonical sequence.

>Q8TBA6|GOLGA5
     1  MSWFVDLAGK AEDLLNRVDQ GAATALSRKD NASNIYSKNT DYTELHQQNT DLIYQTGPKS
    61  TYISSAADNI RNQKATILAG TANVKVGSRT PVEASHPVEN ASVPRPSSHF VRRKKSEPDD
   121  ELLFDFLNSS QKEPTGRVEI RKEKGKTPVF QSSQTSSVSS VNPSVTTIKT IEENSFGSQT
   181  HEAASNSDSS HEGQEESSKE NVSSNAACPD HTPTPNDDGK SHELSNLRLE NQLLRNEVQS
   241  LNQEMASLLQ RSKETQEELN KARARVEKWN ADHSKSDRMT RGLRAQVDDL TEAVAAKDSQ
   301  LAVLKVRLQE ADQLLSTRTE ALEALQSEKS RIMQDQSEGN SLQNQALQTF QERLHEADAT
   361  LKREQESYKQ MQSEFAARLN KVEMERQNLA EAITLAERKY SDEKKRVDEL QQQVKLYKLN
   421  LESSKQELID YKQKATRILQ SKEKLINSLK EGSGFEGLDS STASSMELEE LRHEKEMQRE
   481  EIQKLMGQIH QLRSELQDME AQQVNEAESA REQLQDLHDQ IAGQKASKQE LETELERLKQ
   541  EFHYIEEDLY RTKNTLQSRI KDRDEEIQKL RNQLTNKTLS NSSQSELENR LHQLTETLIQ
   601  KQTMLESLST EKNSLVFQLE RLEQQMNSAS GSSSNGSSIN MSGIDNGEGT RLRNVPVLFN
   661  DTETNLAGMY GKVRKAASSI DQFSIRLGIF LRRYPIARVF VIIYMALLHL WVMIVLLTYT
   721  PEMHHDQPYG K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 51 nTPM
  • liver: 51 nTPM
  • testis: 32 nTPM
  • parathyroid gland: 32 nTPM
  • pancreas: 31 nTPM
  • stomach: 31 nTPM

Single-cell type

  • syncytiotrophoblasts: 100 nCPM
  • sertoli cells: 95 nCPM
  • esophageal apical cells: 92 nCPM
  • lacrimal acinar cells: 72 nCPM
  • somatotrophs: 68 nCPM
  • epididymal principal cells: 68 nCPM

Immune cell

  • eosinophil: 24 nTPM
  • intermediate monocyte: 13 nTPM
  • T-reg: 13 nTPM
  • non-classical monocyte: 12 nTPM
  • MAIT T-cell: 12 nTPM
  • memory CD8 T-cell: 11 nTPM

Brain region

  • white matter: 31 nTPM
  • choroid plexus: 28 nTPM
  • basal ganglia: 27 nTPM
  • medulla oblongata: 26 nTPM
  • spinal cord: 25 nTPM
  • cerebellum: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0
gnomAD missense Z
0.72
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Golgin subfamily A member 5
  • Golgin subfamily A member 5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GOLGA5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA5 as an antibody target. Whether an autoantibody or antibody against GOLGA5 could matter depends on whether native GOLGA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GOLGA5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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