Seroatlas · Human Serome Atlas

NUP88

Nuclear pore complex protein Nup88

Also known as: MGC8530, NUP88_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99567
Gene
NUP88
Ensembl
ENSG00000108559
Chromosome
17
Canonical length
741 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

741 residues, UniProt reviewed canonical sequence.

>Q99567|NUP88
     1  MAAAEGPVGD GELWQTWLPN HVVFLRLREG LKNQSPTEAE KPASSSLPSS PPPQLLTRNV
    61  VFGLGGELFL WDGEDSSFLV VRLRGPSGGG EEPALSQYQR LLCINPPLFE IYQVLLSPTQ
   121  HHVALIGIKG LMVLELPKRW GKNSEFEGGK STVNCSTTPV AERFFTSSTS LTLKHAAWYP
   181  SEILDPHVVL LTSDNVIRIY SLREPQTPTN VIILSEAEEE SLVLNKGRAY TASLGETAVA
   241  FDFGPLAAVP KTLFGQNGKD EVVAYPLYIL YENGETFLTY ISLLHSPGNI GKLLGPLPMH
   301  PAAEDNYGYD ACAVLCLPCV PNILVIATES GMLYHCVVLE GEEEDDHTSE KSWDSRIDLI
   361  PSLYVFECVE LELALKLASG EDDPFDSDFS CPVKLHRDPK CPSRYHCTHE AGVHSVGLTW
   421  IHKLHKFLGS DEEDKDSLQE LSTEQKCFVE HILCTKPLPC RQPAPIRGFW IVPDILGPTM
   481  ICITSTYECL IWPLLSTVHP ASPPLLCTRE DVEVAESPLR VLAETPDSFE KHIRSILQRS
   541  VANPAFLKAS EKDIAPPPEE CLQLLSRATQ VFREQYILKQ DLAKEEIQRR VKLLCDQKKK
   601  QLEDLSYCRE ERKSLREMAE RLADKYEEAK EKQEDIMNRM KKLLHSFHSE LPVLSDSERD
   661  MKKELQLIPD QLRHLGNAIK QVTMKKDYQQ QKMEKVLSLP KPTIILSAYQ RKCIQSILKE
   721  EGEHIREMVK QINDIRNHVN F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUP88 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • testis: 47 nTPM
  • skeletal muscle: 32 nTPM
  • tonsil: 27 nTPM
  • tongue: 25 nTPM
  • thymus: 24 nTPM
  • liver: 22 nTPM

Single-cell type

  • endometrial glandular cells: 267 nCPM
  • late primary spermatocytes: 245 nCPM
  • endometrial luminal cells: 198 nCPM
  • b-cells: 194 nCPM
  • epicardial cells: 166 nCPM
  • myonuclei: 161 nCPM

Immune cell

  • memory B-cell: 40 nTPM
  • naive B-cell: 36 nTPM
  • NK-cell: 21 nTPM
  • T-reg: 18 nTPM
  • non-classical monocyte: 17 nTPM
  • naive CD8 T-cell: 16 nTPM

Brain region

  • cerebellum: 19 nTPM
  • cerebral cortex: 13 nTPM
  • white matter: 12 nTPM
  • medulla oblongata: 11 nTPM
  • pons: 11 nTPM
  • hippocampal formation: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NUP88.

Disease | AllUniProt

Conditions NUP88 is implicated in, by any mechanism.

  • Fetal akinesia deformation sequence 4 (FADS4) MIM:618393

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 170 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Fetal akinesia deformation sequence 4

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0
gnomAD missense Z
-0.53
DepMap mean gene effect
-1.52
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Nucleoporin Nup88
  • Nucleoporin NUP88/NUP82
  • Nuclear pore component

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUP88 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUP88 as an antibody target. Whether an autoantibody or antibody against NUP88 could matter depends on whether native NUP88 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUP88 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUP88 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUP88. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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