Seroatlas · Human Serome Atlas

NUTF2

Nuclear transport factor 2

Also known as: NTF2, NTF2_HUMAN, PP15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61970
Gene: NUTF2
Ensembl: ENSG00000102898
Chromosome: 16
Canonical length: 127 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>P61970|NUTF2
     1  MGDKPIWEQI GSSFIQHYYQ LFDNDRTQLG AIYIDASCLT WEGQQFQGKA AIVEKLSSLP
    61  FQKIQHSITA QDHQPTPDSC IISMVVGQLK ADEDPIMGFH QMFLLKNIND AWVCTNDMFR
   121  LALHNFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUTF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 161 nTPM

Expression across tissuesHPA

Tissue

tongue: 161 nTPM
skeletal muscle: 143 nTPM
heart muscle: 123 nTPM
thymus: 114 nTPM
urinary bladder: 107 nTPM
placenta: 105 nTPM

Single-cell type

extravillous trophoblasts: 411 nCPM
migrating cytotrophoblasts: 382 nCPM
platelets: 375 nCPM
cytotrophoblasts: 224 nCPM
gastric progenitor cells: 212 nCPM
syncytiotrophoblasts: 194 nCPM

Immune cell

total PBMC: 215 nTPM
intermediate monocyte: 192 nTPM
non-classical monocyte: 173 nTPM
myeloid DC: 168 nTPM
plasmacytoid DC: 162 nTPM
T-reg: 144 nTPM

Brain region

hypothalamus: 140 nTPM
pons: 139 nTPM
white matter: 127 nTPM
midbrain: 126 nTPM
medulla oblongata: 126 nTPM
cerebellum: 120 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.94
gnomAD missense Z: 2.29
DepMap mean gene effect: -1.82
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUTF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUTF2 as an antibody target. Whether an autoantibody or antibody against NUTF2 could matter depends on whether native NUTF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUTF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUTF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...