Seroatlas · Human Serome Atlas

TNPO3

Transportin-3

Also known as: IPO12, LGMD1F, MTR10A, TNPO3_HUMAN, TRN-SR, TRN-SR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5L0
Gene
TNPO3
Ensembl
ENSG00000064419
Chromosome
7
Canonical length
923 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Several protein-coding and non-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2020]

Canonical amino-acid sequenceUniProt

923 residues, UniProt reviewed canonical sequence.

>Q9Y5L0|TNPO3
     1  MEGAKPTLQL VYQAVQALYH DPDPSGKERA SFWLGELQRS VHAWEISDQL LQIRQDVESC
    61  YFAAQTMKMK IQTSFYELPT DSHASLRDSL LTHIQNLKDL SPVIVTQLAL AIADLALQMP
   121  SWKGCVQTLV EKYSNDVTSL PFLLEILTVL PEEVHSRSLR IGANRRTEII EDLAFYSSTV
   181  VSLLMTCVEK AGTDEKMLMK VFRCLGSWFN LGVLDSNFMA NNKLLALLFE VLQQDKTSSN
   241  LHEAASDCVC SALYAIENVE TNLPLAMQLF QGVLTLETAY HMAVAREDLD KVLNYCRIFT
   301  ELCETFLEKI VCTPGQGLGD LRTLELLLIC AGHPQYEVVE ISFNFWYRLG EHLYKTNDEV
   361  IHGIFKAYIQ RLLHALARHC QLEPDHEGVP EETDDFGEFR MRVSDLVKDL IFLIGSMECF
   421  AQLYSTLKEG NPPWEVTEAV LFIMAAIAKS VDPENNPTLV EVLEGVVRLP ETVHTAVRYT
   481  SIELVGEMSE VVDRNPQFLD PVLGYLMKGL CEKPLASAAA KAIHNICSVC RDHMAQHFNG
   541  LLEIARSLDS FLLSPEAAVG LLKGTALVLA RLPLDKITEC LSELCSVQVM ALKKLLSQEP
   601  SNGISSDPTV FLDRLAVIFR HTNPIVENGQ THPCQKVIQE IWPVLSETLN KHRADNRIVE
   661  RCCRCLRFAV RCVGKGSAAL LQPLVTQMVN VYHVHQHSCF LYLGSILVDE YGMEEGCRQG
   721  LLDMLQALCI PTFQLLEQQN GLQNHPDTVD DLFRLATRFI QRSPVTLLRS QVVIPILQWA
   781  IASTTLDHRD ANCSVMRFLR DLIHTGVAND HEEDFELRKE LIGQVMNQLG QQLVSQLLHT
   841  CCFCLPPYTL PDVAEVLWEI MQVDRPTFCR WLENSLKGLP KETTVGAVTV THKQLTDFHK
   901  QVTSAEECKQ VCWALRDFTR LFR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNPO3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 31 nTPM
  • skeletal muscle: 30 nTPM
  • thymus: 27 nTPM
  • tonsil: 26 nTPM
  • testis: 24 nTPM
  • tongue: 24 nTPM

Single-cell type

  • neutrophils: 482 nCPM
  • neutrophil progenitors: 430 nCPM
  • monocyte progenitors: 187 nCPM
  • podocytes: 149 nCPM
  • adrenal cortex cells: 137 nCPM
  • endometrial glandular cells: 134 nCPM

Immune cell

  • basophil: 27 nTPM
  • non-classical monocyte: 24 nTPM
  • eosinophil: 22 nTPM
  • intermediate monocyte: 17 nTPM
  • gdT-cell: 16 nTPM
  • memory B-cell: 16 nTPM

Brain region

  • hypothalamus: 38 nTPM
  • pons: 37 nTPM
  • cerebellum: 35 nTPM
  • thalamus: 34 nTPM
  • midbrain: 33 nTPM
  • white matter: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TNPO3.

Disease | AllUniProt

Conditions TNPO3 is implicated in, by any mechanism.

  • Muscular dystrophy, limb-girdle, autosomal dominant 2 (LGMDD2) MIM:608423

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 804 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Autosomal dominant limb-girdle muscular dystrophy type 1F
  • Muscular dystrophy, limb-girdle, autosomal dominant

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0
gnomAD missense Z
3.44
DepMap mean gene effect
-1.4
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNPO3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNPO3 as an antibody target. Whether an autoantibody or antibody against TNPO3 could matter depends on whether native TNPO3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNPO3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNPO3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TNPO3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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