Seroatlas · Human Serome Atlas

NUP58

Nucleoporin p58/p45

Also known as: KIAA0410, NUP45, NUP58_HUMAN, NUPL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVL2
Gene: NUP58
Ensembl: ENSG00000139496
Chromosome: 13
Canonical length: 599 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

599 residues, UniProt reviewed canonical sequence.

>Q9BVL2|NUP58
     1  MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST STPATTSAPS
    61  SGFGTGLFGS KPATGFTLGG TNTGIATTIT TGLTLGTPAT TSAATTGFSL GFNKPAASAT
   121  PFALPITSTS ASGLTLSSAL TSTPAASTGF TLNNLGGTTA TTTTASTGLS LGGALAGLGG
   181  SLFQSTNTGT SGLGQNALGL TLGTTAATST AGNEGLGGID FSSSSDKKSD KTGTRPEDSK
   241  ALKDENLPPV ICQDVENLQK FVKEQKQVQE EISRMSSKAM LKVQEDIKAL KQLLSLAANG
   301  IQRNTLNIDK LKIETAQELK NAEIALRTQK TPPGLQHEYA APADYFRILV QQFEVQLQQY
   361  RQQIEELENH LATQANNSHI TPQDLSMAMQ KIYQTFVALA AQLQSIHENV KVLKEQYLGY
   421  RKMFLGDAVD VFETRRAEAK KWQNTPRVTT GPTPFSTMPN AAAVAMAATL TQQQQPATGP
   481  QPSLGVSFGT PFGSGIGTGL QSSGLGSSNL GGFGTSSGFG CSTTGASTFG FGTTNKPSGS
   541  LSAGFGSSST SGFNFSNPGI TASAGLTFGV SNPASAGFGT GGQLLQLKKP PAGNKRGKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUP58 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

testis: 42 nTPM
thymus: 25 nTPM
retina: 24 nTPM
tongue: 22 nTPM
pituitary gland: 20 nTPM
lymph node: 19 nTPM

Single-cell type

neutrophils: 626 nCPM
late spermatids: 400 nCPM
monocytes: 203 nCPM
alveolar cells type 2: 194 nCPM
neutrophil progenitors: 177 nCPM
early spermatids: 160 nCPM

Immune cell

neutrophil: 8.2 nTPM
classical monocyte: 6.4 nTPM
non-classical monocyte: 6.1 nTPM
intermediate monocyte: 5.3 nTPM
T-reg: 4 nTPM
myeloid DC: 3.8 nTPM

Brain region

cerebellum: 32 nTPM
cerebral cortex: 32 nTPM
white matter: 29 nTPM
midbrain: 29 nTPM
hypothalamus: 28 nTPM
hippocampal formation: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.93
DepMap mean gene effect: -0.68
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleoporin p58/p45/NUP49
Nucleoporin FG repeated region

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUP58 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUP58 as an antibody target. Whether an autoantibody or antibody against NUP58 could matter depends on whether native NUP58 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUP58 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUP58 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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