Seroatlas · Human Serome Atlas

CCHCR1

Coiled-coil alpha-helical rod protein 1

Also known as: C6orf18, CCHCR_HUMAN, HCR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TD31
Gene
CCHCR1
Ensembl
ENSG00000204536
Chromosome
6
Canonical length
782 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

782 residues, UniProt reviewed canonical sequence.

>Q8TD31|CCHCR1
     1  MFPPSGSTGL IPPSHFQARP LSTLPRMAPT WLSDIPLVQP PGHQDVSERR LDTQRPQVTM
    61  WERDVSSDRQ EPGRRGRSWG LEGSQALSQQ AEVIVRQLQE LRRLEEEVRL LRETSLQQKM
   121  RLEAQAMELE ALARAEKAGR AEAEGLRAAL AGAEVVRKNL EEGSQRELEE VQRLHQEQLS
   181  SLTQAHEEAL SSLTSKAEGL EKSLSSLETR RAGEAKELAE AQREAELLRK QLSKTQEDLE
   241  AQVTLVENLR KYVGEQVPSE VHSQTWELER QKLLETMQHL QEDRDSLHAT AELLQVRVQS
   301  LTHILALQEE ELTRKVQPSD SLEPEFTRKC QSLLNRWREK VFALMVQLKA QELEHSDSVK
   361  QLKGQVASLQ EKVTSQSQEQ AILQRSLQDK AAEVEVERMG AKGLQLELSR AQEARRRWQQ
   421  QTASAEEQLR LVVNAVSSSQ IWLETTMAKV EGAAAQLPSL NNRLSYAVRK VHTIRGLIAR
   481  KLALAQLRQE SCPLPPPVTD VSLELQQLRE ERNRLDAELQ LSARLIQQEV GRAREQGEAE
   541  RQQLSKVAQQ LEQELQQTQE SLASLGLQLE VARQGQQEST EEAASLRQEL TQQQELYGQA
   601  LQEKVAEVET RLREQLSDTE RRLNEARREH AKAVVSLRQI QRRAAQEKER SQELRRLQEE
   661  ARKEEGQRLA RRLQELERDK NLMLATLQQE GLLSRYKQQR LLTVLPSLLD KKKSVVSSPR
   721  PPECSASAPV AAAVPTRESI KGSLSVLLDD LQDLSEAISK EEAVCQGDNL DRCSSSNPQM
   781  SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCHCR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
129 nTPM

Expression across tissuesHPA

Tissue

  • testis: 129 nTPM
  • kidney: 21 nTPM
  • prostate: 18 nTPM
  • ovary: 17 nTPM
  • skeletal muscle: 17 nTPM
  • fallopian tube: 16 nTPM

Single-cell type

  • late spermatids: 175 nCPM
  • late primary spermatocytes: 96 nCPM
  • early spermatids: 57 nCPM
  • endometrial glandular cells: 29 nCPM
  • early primary spermatocytes: 29 nCPM
  • endometrial luminal cells: 28 nCPM

Immune cell

  • memory CD8 T-cell: 1.5 nTPM
  • T-reg: 1.5 nTPM
  • naive CD4 T-cell: 1.4 nTPM
  • naive CD8 T-cell: 1.3 nTPM
  • plasmacytoid DC: 1.2 nTPM
  • NK-cell: 1.1 nTPM

Brain region

  • hypothalamus: 4.5 nTPM
  • cerebral cortex: 4.4 nTPM
  • pons: 4.2 nTPM
  • choroid plexus: 3.7 nTPM
  • medulla oblongata: 3.7 nTPM
  • cerebellum: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
1.91
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil alpha-helical rod protein 1
  • Alpha helical coiled-coil rod protein (HCR)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCHCR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCHCR1 as an antibody target. Whether an autoantibody or antibody against CCHCR1 could matter depends on whether native CCHCR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCHCR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCHCR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCHCR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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