Seroatlas · Human Serome Atlas

XPO6

Exportin-6

Also known as: FLJ22519, KIAA0370, RANBP20, XPO6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96QU8
Gene
XPO6
Ensembl
ENSG00000169180
Chromosome
16
Canonical length
1125 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

1125 residues, UniProt reviewed canonical sequence.

>Q96QU8|XPO6
     1  MASEEASLRA LESLMTEFFH DCTTNERKRE IEELLNNFAQ QIGAWRFCLY FLSSTRNDYV
    61  MMYSLTVFEN LINKMWLGVP SQDKMEIRSC LPKLLLAHHK TLPYFIRNKL CKVIVDIGRQ
   121  DWPMFYHDFF TNILQLIQSP VTTPLGLIML KTTSEELACP REDLSVARKE ELRKLLLDQV
   181  QTVLGLLTGI LETVWDKHSV TAATPPPSPT SGESGDLLSN LLQSPSSAKL LNQPIPILDV
   241  ESEYICSLAL ECLAHLFSWI PLSASITPSL LTTIFHFARF GCDIRARKMA SVNGSSQNCV
   301  SGQERGRLGV LAMSCINELM SKNCVPMEFE EYLLRMFQQT FYLLQKITKD NNAHTVKSRL
   361  EELDESYIEK FTDFLRLFVS VHLRRIESYS QFPVVEFLTL LFKYTFHQPT HEGYFSCLDI
   421  WTLFLDYLTS KIKSRLGDKE AVLNRYEDAL VLLLTEVLNR IQFRYNQAQL EELDDETLDD
   481  DQQTEWQRYL RQSLEVVAKV MELLPTHAFS TLFPVLQDNL EVYLGLQQFI VTSGSGHRLN
   541  ITAENDCRRL HCSLRDLSSL LQAVGRLAEY FIGDVFAARF NDALTVVERL VKVTLYGSQI
   601  KLYNIETAVP SVLKPDLIDV HAQSLAALQA YSHWLAQYCS EVHRQNTQQF VTLISTTMDA
   661  ITPLISTKVQ DKLLLSACHL LVSLATTVRP VFLISIPAVQ KVFNRITDAS ALRLVDKAQV
   721  LVCRALSNIL LLPWPNLPEN EQQWPVRSIN HASLISALSR DYRNLKPSAV APQRKMPLDD
   781  TKLIIHQTLS VLEDIVENIS GESTKSRQIC YQSLQESVQV SLALFPAFIH QSDVTDEMLS
   841  FFLTLFRGLR VQMGVPFTEQ IIQTFLNMFT REQLAESILH EGSTGCRVVE KFLKILQVVV
   901  QEPGQVFKPF LPSIIALCME QVYPIIAERP SPDVKAELFE LLFRTLHHNW RYFFKSTVLA
   961  SVQRGIAEEQ MENEPQFSAI MQAFGQSFLQ PDIHLFKQNL FYLETLNTKQ KLYHKKIFRT
  1021  AMLFQFVNVL LQVLVHKSHD LLQEEIGIAI YNMASVDFDG FFAAFLPEFL TSCDGVDANQ
  1081  KSVLGRNFKM DRDLPSFTQN VHRLVNDLRY YRLCNDSLPP GTVKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XPO6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
157 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 157 nTPM
  • testis: 97 nTPM
  • hippocampal formation: 91 nTPM
  • bone marrow: 87 nTPM
  • midbrain: 81 nTPM
  • spinal cord: 80 nTPM

Single-cell type

  • neutrophils: 2,960 nCPM
  • neutrophil progenitors: 287 nCPM
  • nk-cells: 150 nCPM
  • t-cells: 141 nCPM
  • erythrocyte progenitors: 119 nCPM
  • oligodendrocytes: 116 nCPM

Immune cell

  • neutrophil: 203 nTPM
  • eosinophil: 33 nTPM
  • naive CD8 T-cell: 23 nTPM
  • basophil: 21 nTPM
  • memory B-cell: 21 nTPM
  • naive CD4 T-cell: 18 nTPM

Brain region

  • medulla oblongata: 93 nTPM
  • white matter: 92 nTPM
  • pons: 89 nTPM
  • cerebral cortex: 88 nTPM
  • hypothalamus: 85 nTPM
  • hippocampal formation: 84 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.08
gnomAD pLI
1
gnomAD missense Z
3.48
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of XPO6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads XPO6 as an antibody target. Whether an autoantibody or antibody against XPO6 could matter depends on whether native XPO6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

XPO6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label XPO6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/XPO6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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