Seroatlas · Human Serome Atlas

BORCS6

BLOC-1-related complex subunit 6

Also known as: BORC6_HUMAN, C17orf59, FLJ20014

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96GS4
Gene: BORCS6
Ensembl: ENSG00000196544
Chromosome: 17
Canonical length: 357 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Enables identical protein binding activity. Involved in lysosome localization. Part of BORC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>Q96GS4|BORCS6
     1  MESSRGRPGP ETDLLAVAEH QALVFGGGPG RTSSEPPAGL RVSGEEETEN VGGANRHPRT
    61  SPKTSSCGVV HRPEREALEN EPGPQGTLSG AGSRRGAPGA EHEPSLSSRH KNPAPPEGKP
   121  SSGRDCRRGG PGGGMDVEQQ EEEDNDEEAA AGSRAGRSFS SRLQDSRSLD GLSEACGGAG
   181  SSGSAESGAG GGRRATISSP LELEGTVSRH GDLTHFVANN LQLKIRLSGA PPPPPSAPAR
   241  PCPAPAPTPT PAIPPIDPEV LRDLERLSRE LGGRVDRLLR GLGGAVQELT ALSVGCIQTY
   301  RDAVDSLGEA VDMSIKGMYT LLARCEELER ALQPVQGLAR QVRDIRRTLE VLEALCK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BORCS6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 21 nTPM
pancreas: 20 nTPM
skin: 16 nTPM
spleen: 16 nTPM
esophagus: 15 nTPM
heart muscle: 14 nTPM

Single-cell type

platelets: 110 nCPM
esophageal apical cells: 43 nCPM
esophageal suprabasal cells: 32 nCPM
enterocytes: 28 nCPM
hofbauer cells: 27 nCPM
cytotrophoblasts: 25 nCPM

Immune cell

eosinophil: 51 nTPM
basophil: 47 nTPM
memory CD8 T-cell: 30 nTPM
NK-cell: 29 nTPM
gdT-cell: 28 nTPM
naive CD8 T-cell: 25 nTPM

Brain region

medulla oblongata: 17 nTPM
cerebral cortex: 16 nTPM
white matter: 15 nTPM
pons: 15 nTPM
midbrain: 14 nTPM
cerebellum: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0.2
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

BLOC-1-related complex subunit 6
BLOC-1-related complex subunit 6, C-terminal helix
BLOC-1-related complex sub-unit 6 C-terminal helix

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BORCS6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BORCS6 as an antibody target. Whether an autoantibody or antibody against BORCS6 could matter depends on whether native BORCS6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BORCS6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BORCS6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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