LAMP2

Protein identityUniProt · HPA

UniProt accession

P13473

Gene

LAMP2

Ensembl

ENSG00000005893

Chromosome

X

Canonical length

410 aa

Protein class

CD markers, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters

Subcellular location

Vesicles

Quaternary structure

Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>P13473|LAMP2
     1  MVCFRLFPVP GSGLVLVCLV LGAVRSYALE LNLTDSENAT CLYAKWQMNF TVRYETTNKT
    61  YKTVTISDHG TVTYNGSICG DDQNGPKIAV QFGPGFSWIA NFTKAASTYS IDSVSFSYNT
   121  GDNTTFPDAE DKGILTVDEL LAIRIPLNDL FRCNSLSTLE KNDVVQHYWD VLVQAFVQNG
   181  TVSTNEFLCD KDKTSTVAPT IHTTVPSPTT TPTPKEKPEA GTYSVNNGND TCLLATMGLQ
   241  LNITQDKVAS VININPNTTH STGSCRSHTA LLRLNSSTIK YLDFVFAVKN ENRFYLKEVN
   301  ISMYLVNGSV FSIANNNLSY WDAPLGSSYM CNKEQTVSVS GAFQINTFDL RVQPFNVTQG
   361  KYSTAQDCSA DDDNFLVPIA VGAALAGVLI LVLLAYFIGL KHHHAGYEQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAMP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

142 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LAMP2.

Disease | AllUniProt

Conditions LAMP2 is implicated in, by any mechanism.

• Danon disease (DAND) MIM:300257

Disease | GeneticClinVar

148 pathogenic / likely-pathogenic of 936 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Danon disease
• Cardiovascular phenotype
• Hypertrophic cardiomyopathy
• Primary dilated cardiomyopathy
• Thyroid cancer, nonmedullary, 1

Disease | AutoantibodyPubMed

Conditions in which antibodies against LAMP2 are reported. Each links to that disease's full target list.

• Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 7
• Glomerulonephritis 5

ReferencesPubMed · IEDB

Publications for LAMP2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.64

gnomAD pLI

0.27

gnomAD missense Z

0.84

DepMap mean gene effect

0.18

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• autophagosome maturation
• cellular response to starvation
• chaperone-mediated autophagy
• lysosomal lumen acidification
• lysosomal protein catabolic process
• muscle cell cellular homeostasis
• negative regulation of NLRP3 inflammasome complex assembly
• negative regulation of protein-containing complex assembly
• positive regulation of ferroptosis
• protein catabolic process
• protein import
• protein stabilization
• protein targeting
• protein targeting to lysosome involved in chaperone-mediated autophagy
• regulation of protein stability

Molecular functions

• enzyme binding
• ion channel inhibitor activity
• protein domain specific binding
• protein-macromolecule adaptor activity
• signaling adaptor activity

Cellular components

• autolysosome
• autophagosome membrane
• azurophil granule membrane
• extracellular exosome
• extracellular space
• ficolin-1-rich granule membrane
• late endosome
• late endosome membrane
• lysosomal lumen
• lysosomal membrane
• lysosome
• membrane
• perinuclear region of cytoplasm
• phagocytic vesicle membrane
• plasma membrane
• platelet dense granule membrane
• trans-Golgi network
• chaperone-mediated autophagy translocation complex

Protein domainsUniProt · Pfam · InterPro

• Lysosome-associated membrane glycoprotein
• Lysosome-associated membrane glycoprotein, conserved site
• Lysosome-associated membrane glycoprotein 2-like, transmembrane domain
• Lysosome-associated membrane glycoprotein 2-like, luminal domains
• Lysosome-associated membrane glycoprotein 2-like, luminal domains
• Lysosome-associated membrane glycoprotein 2, transmembrane segment

KeywordsUniProt

• Autophagy
• Cell membrane
• Cytoplasmic vesicle
• Disulfide bond
• Endosome
• Glycogen storage disease
• Glycoprotein
• Lysosome
• Membrane
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of LAMP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ABCB9
• CT55
• FURIN
• HSP90
• MLLT11
• TMEM175
• SIDT2
• AP4M1
• CANX
• LAMTOR1
• TMEM192