Seroatlas · Human Serome Atlas

WDR11

WD repeat-containing protein 11

Also known as: BRWD2, DR11, FLJ10506, HH14, KIAA1351, SRI1, WDR11_HUMAN, WDR15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZH6
Gene: WDR11
Ensembl: ENSG00000120008
Chromosome: 10
Canonical length: 1224 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Microtubules,Primary cilium,Cytosol,Flagellar centriole,Principal piece,End piece

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1224 residues, UniProt reviewed canonical sequence.

>Q9BZH6|WDR11
     1  MLPYTVNFKV SARTLTGALN AHNKAAVDWG WQGLIAYGCH SLVVVIDSIT AQTLQVLEKH
    61  KADVVKVKWA RENYHHNIGS PYCLRLASAD VNGKIIVWDV AAGVAQCEIQ EHAKPIQDVQ
   121  WLWNQDASRD LLLAIHPPNY IVLWNADTGT KLWKKSYADN ILSFSFDPFD PSHLTLLTSE
   181  GIVFISDFSP SKPPSGPGKK VYISSPHSSP AHNKLATATG AKKALNKVKI LITQEKPSAE
   241  FITLNDCLQL AYLPSKRNHM LLLYPREILI LDLEVNQTVG VIAIERTGVP FLQVIPCFQR
   301  DGLFCLHENG CITLRVRRSY NNIFTTSNEE PDPDPVQELT YDLRSQCDAI RVTKTVRPFS
   361  MVCCPVNENA AALVVSDGRV MIWELKSAVC NRNSRNSSSG VSPLYSPVSF CGIPVGVLQN
   421  KLPDLSLDNM IGQSAIAGEE HPRGSILREV HLKFLLTGLL SGLPAPQFAI RMCPPLTTKN
   481  IKMYQPLLAV GTSNGSVLVY HLTSGLLHKE LSIHSCEVKG IEWTSLTSFL SFATSTPNNM
   541  GLVRNELQLV DLPTGRSIAF RGERGNDESA IEMIKVSHLK QYLAVVFRDK PLELWDVRTC
   601  TLLREMSKNF PTITALEWSP SHNLKSLRKK QLATREAMAR QTVVSDTELS IVESSVISLL
   661  QEAESKSELS QNISAREHFV FTDIDGQVYH LTVEGNSVKD SARIPPDGSM GSITCIAWKG
   721  DTLVLGDMDG NLNFWDLKGR VSRGIPTHRS WVRKIRFAPG KGNQKLIAMY NDGAEVWDTK
   781  EVQMVSSLRS GRNVTFRILD VDWCTSDKVI LASDDGCIRV LEMSMKSACF RMDEQELTEP
   841  VWCPYLLVPR ASLALKAFLL HQPWNGQYSL DISHVDYPEN EEIKNLLQEQ LNSLSNDIKK
   901  LLLDPEFTLL QRCLLVSRLY GDESELHFWT VAAHYLHSLS QEKSASTTAP KEAAPRDKLS
   961  NPLDICYDVL CENAYFQKFQ LERVNLQEVK RSTYDHTRKC TDQLLLLGQT DRAVQLLLET
  1021  SADNQHYYCD SLKACLVTTV TSSGPSQSTI KLVATNMIAN GKLAEGVQLL CLIDKAADAC
  1081  RYLQTYGEWN RAAWLAKVRL NPEECADVLR RWVDHLCSPQ VNQKSKALLV LLSLGCFFSV
  1141  AETLHSMRYF DRAALFVEAC LKYGAFEVTE DTEKLITAIY ADYARSLKNL GFKQGAVLFA
  1201  SKAGAAGKDL LNELESPKEE PIEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 36 nTPM
kidney: 23 nTPM
thyroid gland: 21 nTPM
tonsil: 19 nTPM
liver: 19 nTPM
lymph node: 17 nTPM

Single-cell type

gastric progenitor cells: 488 nCPM
bergmann glia: 212 nCPM
oligodendrocyte progenitor cells: 150 nCPM
astrocytes: 136 nCPM
adrenal cortex cells: 115 nCPM
distal convoluted tubule cells: 102 nCPM

Immune cell

basophil: 28 nTPM
non-classical monocyte: 25 nTPM
intermediate monocyte: 11 nTPM
myeloid DC: 9.7 nTPM
memory B-cell: 8.6 nTPM
classical monocyte: 8.5 nTPM

Brain region

white matter: 35 nTPM
choroid plexus: 28 nTPM
pons: 27 nTPM
spinal cord: 26 nTPM
medulla oblongata: 25 nTPM
hypothalamus: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR11.

Disease | AllUniProt

Conditions WDR11 is implicated in, by any mechanism.

Hypogonadotropic hypogonadism 14 with or without anosmia (HH14) MIM:614858
Intellectual developmental disorder, autosomal recessive 78 (MRT78) MIM:620237

Disease | GeneticClinVar

18 pathogenic / likely-pathogenic of 535 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual developmental disorder, autosomal recessive 78
Hypogonadotropic hypogonadism 14 with or without anosmia
Microcephaly
WDR11-related disorder
Hypogonadotropic hypogonadism 14 with anosmia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0
gnomAD missense Z: 1.8
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40 repeat, conserved site
WD40-repeat-containing domain superfamily
WD repeat-containing protein 11
WDR11, first beta-propeller
WDR11, second beta-propeller
WDR11, TPR domain
WDR11 first beta-propeller
WDR11 second beta-propeller
WDR11 TPR domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR11 as an antibody target. Whether an autoantibody or antibody against WDR11 could matter depends on whether native WDR11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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