Seroatlas · Human Serome Atlas

TMEM160

Transmembrane protein 160

Also known as: FLJ20512, TM160_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NX00
Gene: TMEM160
Ensembl: ENSG00000130748
Chromosome: 19
Canonical length: 188 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q9NX00|TMEM160
     1  MGGGWWWARA ARLARLRFRR SLLPPQRPRS GGARGSFAPG HGPRAGASPP PVSELDRADA
    61  WLLRKAHETA FLSWFRNGLL ASGIGVISFM QSDMGREAAY GFFLLGGLCV VWGSASYAVG
   121  LAALRGPMQL TLGGAAVGAG AVLAASLLWA CAVGLYMGQL ELDVELVPED DGTASAEGPD
   181  EAGRPPPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM160 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

amygdala: 100 nTPM
hippocampal formation: 90 nTPM
cerebral cortex: 82 nTPM
midbrain: 53 nTPM
basal ganglia: 50 nTPM
hypothalamus: 41 nTPM

Single-cell type

late spermatids: 433 nCPM
esophageal suprabasal cells: 205 nCPM
esophageal basal cells: 201 nCPM
hofbauer cells: 200 nCPM
enterocytes: 189 nCPM
oocytes: 166 nCPM

Immune cell

eosinophil: 63 nTPM
memory CD8 T-cell: 51 nTPM
naive B-cell: 50 nTPM
T-reg: 46 nTPM
plasmacytoid DC: 46 nTPM
memory CD4 T-cell: 45 nTPM

Brain region

cerebral cortex: 100 nTPM
amygdala: 93 nTPM
hippocampal formation: 92 nTPM
medulla oblongata: 83 nTPM
pons: 82 nTPM
white matter: 80 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0.1
gnomAD missense Z: 1.06
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 160

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM160 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KBTBD7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM160 as an antibody target. Whether an autoantibody or antibody against TMEM160 could matter depends on whether native TMEM160 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM160 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM160 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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