Seroatlas · Human Serome Atlas

RBFA

Putative ribosome-binding factor A, mitochondrial

Also known as: C18orf22, FLJ21172, HsT169, RBFA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N0V3
Gene: RBFA
Ensembl: ENSG00000101546
Chromosome: 18
Canonical length: 343 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be involved in rRNA processing. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>Q8N0V3|RBFA
     1  MWAAAGGLWR SRAGLRALFR SRDAALFPGC ERGLHCSAVS CKNWLKKFAS KTKKKVWYES
    61  PSLGSHSTYK PSKLEFLMRS TSKKTRKEDH ARLRALNGLL YKALTDLLCT PEVSQELYDL
   121  NVELSKVSLT PDFSACRAYW KTTLSAEQNA HMEAVLQRSA AHMRHLLMSQ QTLRNVPPIV
   181  FVQDKGNAAL AELDQLLAVA DFGPRDERDN FVQNDFRDPD APQPCGTTEP TTSSSLCGID
   241  HEALNKQIME YKRRKDKGLG GLVWQGQVAE LTTQMKKGRK RAKPRLEQDS SLKSYLSGEE
   301  VEDDLDLVGA PEYECYAPDT EELEAERGGG RTEDGHSCGA SRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBFA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

liver: 26 nTPM
skeletal muscle: 19 nTPM
adrenal gland: 17 nTPM
skin: 17 nTPM
heart muscle: 15 nTPM
adipose tissue: 15 nTPM

Single-cell type

erythrocyte progenitors: 5.4 nCPM
conjunctival goblet cells: 4.9 nCPM
megakaryocyte progenitors: 4.8 nCPM
urothelial cells: 4.7 nCPM
granulosa cells: 4.1 nCPM
fallopian secretory cells: 4 nCPM

Immune cell

non-classical monocyte: 10 nTPM
MAIT T-cell: 10 nTPM
memory B-cell: 8.9 nTPM
myeloid DC: 7.6 nTPM
naive CD4 T-cell: 7.4 nTPM
NK-cell: 7.3 nTPM

Brain region

cerebellum: 15 nTPM
basal ganglia: 11 nTPM
cerebral cortex: 11 nTPM
hypothalamus: 11 nTPM
white matter: 11 nTPM
amygdala: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: -0.38
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

K homology domain-like, alpha/beta
Ribosome-binding factor A
Ribosome-binding factor A, conserved site
Ribosome-binding factor A domain superfamily
Ribosome-binding factor A, mitochondrial
Ribosome-binding factor A

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBFA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBFA as an antibody target. Whether an autoantibody or antibody against RBFA could matter depends on whether native RBFA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBFA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBFA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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