Seroatlas · Human Serome Atlas

ILKAP

Integrin-linked kinase-associated serine/threonine phosphatase 2C

Also known as: DKFZP434J2031, FLJ10181, ILKAP_HUMAN, PPM1O

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0C8
Gene: ILKAP
Ensembl: ENSG00000132323
Chromosome: 2
Canonical length: 392 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

392 residues, UniProt reviewed canonical sequence.

>Q9H0C8|ILKAP
     1  MDLFGDLPEP ERSPRPAAGK EAQKGPLLFD DLPPASSTDS GSGGPLLFDD LPPASSGDSG
    61  SLATSISQMV KTEGKGAKRK TSEEEKNGSE ELVEKKVCKA SSVIFGLKGY VAERKGEREE
   121  MQDAHVILND ITEECRPPSS LITRVSYFAV FDGHGGIRAS KFAAQNLHQN LIRKFPKGDV
   181  ISVEKTVKRC LLDTFKHTDE EFLKQASSQK PAWKDGSTAT CVLAVDNILY IANLGDSRAI
   241  LCRYNEESQK HAALSLSKEH NPTQYEERMR IQKAGGNVRD GRVLGVLEVS RSIGDGQYKR
   301  CGVTSVPDIR RCQLTPNDRF ILLACDGLFK VFTPEEAVNF ILSCLEDEKI QTREGKSAAD
   361  ARYEAACNRL ANKAVQRGSA DNVTVMVVRI GH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ILKAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 41 nTPM
cerebellum: 38 nTPM
colon: 31 nTPM
bone marrow: 27 nTPM
pituitary gland: 27 nTPM
cervix: 27 nTPM

Single-cell type

somatotrophs: 125 nCPM
oligodendrocytes: 114 nCPM
thyrotrophs: 110 nCPM
lactotrophs: 108 nCPM
nk-cells: 102 nCPM
early primary spermatocytes: 97 nCPM

Immune cell

basophil: 44 nTPM
T-reg: 31 nTPM
naive CD4 T-cell: 29 nTPM
gdT-cell: 28 nTPM
myeloid DC: 28 nTPM
eosinophil: 27 nTPM

Brain region

white matter: 20 nTPM
cerebellum: 19 nTPM
basal ganglia: 17 nTPM
cerebral cortex: 16 nTPM
medulla oblongata: 15 nTPM
hypothalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
gnomAD missense Z: 2.21
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ILKAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ILKAP as an antibody target. Whether an autoantibody or antibody against ILKAP could matter depends on whether native ILKAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ILKAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ILKAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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