Seroatlas · Human Serome Atlas

PARVG

Gamma-parvin

Also known as: PARVG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBI0
Gene: PARVG
Ensembl: ENSG00000138964
Chromosome: 22
Canonical length: 331 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Members of the parvin family, including PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM, Aug 2004]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q9HBI0|PARVG
     1  MEPEFLYDLL QLPKGVEPPA EEELSKGGKK KYLPPTSRKD PKFEELQKVL MEWINATLLP
    61  EHIVVRSLEE DMFDGLILHH LFQRLAALKL EAEDIALTAT SQKHKLTVVL EAVNRSLQLE
   121  EWQAKWSVES IFNKDLLSTL HLLVALAKRF QPDLSLPTNV QVEVITIEST KSGLKSEKLV
   181  EQLTEYSTDK DEPPKDVFDE LFKLAPEKVN AVKEAIVNFV NQKLDRLGLS VQNLDTQFAD
   241  GVILLLLIGQ LEGFFLHLKE FYLTPNSPAE MLHNVTLALE LLKDEGLLSC PVSPEDIVNK
   301  DAKSTLRVLY GLFCKHTQKA HRDRTPHGAP N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARVG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 47 nTPM
lymph node: 28 nTPM
spleen: 28 nTPM
appendix: 25 nTPM
tonsil: 25 nTPM
thymus: 17 nTPM

Single-cell type

monocyte progenitors: 143 nCPM
monocytes: 139 nCPM
cdc: 125 nCPM
pdcs: 109 nCPM
macrophages: 98 nCPM
neutrophil progenitors: 95 nCPM

Immune cell

neutrophil: 73 nTPM
eosinophil: 72 nTPM
non-classical monocyte: 67 nTPM
classical monocyte: 63 nTPM
intermediate monocyte: 58 nTPM
myeloid DC: 50 nTPM

Brain region

white matter: 17 nTPM
medulla oblongata: 15 nTPM
thalamus: 15 nTPM
pons: 12 nTPM
cerebral cortex: 10 nTPM
spinal cord: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

actin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARVG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARVG as an antibody target. Whether an autoantibody or antibody against PARVG could matter depends on whether native PARVG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARVG is annotated at the cell surface, where native PARVG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PARVG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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